MED14_ASPFU
ID MED14_ASPFU Reviewed; 1093 AA.
AC Q4WH96;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE AltName: Full=Mediator complex subunit 14;
GN Name=rgr1; Synonyms=med14; ORFNames=AFUA_2G06180;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC {ECO:0000305}.
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DR EMBL; AAHF01000008; EAL87709.1; -; Genomic_DNA.
DR RefSeq; XP_749747.1; XM_744654.1.
DR AlphaFoldDB; Q4WH96; -.
DR STRING; 746128.CADAFUBP00002269; -.
DR EnsemblFungi; EAL87709; EAL87709; AFUA_2G06180.
DR GeneID; 3506639; -.
DR KEGG; afm:AFUA_2G06180; -.
DR VEuPathDB; FungiDB:Afu2g06180; -.
DR eggNOG; KOG1875; Eukaryota.
DR HOGENOM; CLU_003573_1_1_1; -.
DR InParanoid; Q4WH96; -.
DR OMA; FAHAKRA; -.
DR OrthoDB; 1215335at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR013947; Mediator_Med14.
DR PANTHER; PTHR12809; PTHR12809; 1.
DR Pfam; PF08638; Med14; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1093
FT /note="Mediator of RNA polymerase II transcription subunit
FT 14"
FT /id="PRO_0000304593"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1093 AA; 121221 MW; B10E71770D74A619 CRC64;
MPGVIMDNAT TGRPGHAPDT QTPSNGDNLR NGSFHINGAA KGDKDHDPDK ESYAGKPRID
GHRALPEIPH ITQGFFPFST LVNRSVQQCW NELSDLITEL AAIHVSPHSS VPLLPVNGKS
PGNQSPENVQ KKLRILDFAH AKRAEFIKLL VLSQWSRRAR DVSKLIDLQN FIRARHQAFV
DALQRVGEMK RDLVQAQVAN PDLQTALEIL SKGRLESLAD LGYKSSKLLT ARGALRRLHK
INRIISARLA LHDLIPHPFR TYRVHDGRVT FVVRGEFELD LSIGAESELS QFFFVDIRFL
YSPSSNIPKG RMSNEIDAKI NEKLRDSGLT GCFNFLHGLV LTNKIHILFK QAIELAKGLW
SETLRVELLH RTLVIQYWTL KPGPKSWIEI GVKSGNGDAD SQGLGVPCLG LRWMRDGQEV
NSRDIEFDPE DLSMECLLRS VIALHISYLL SSAYGILSEY SLFSSGTLSS HAILNVTEPG
ECQLSVQLTG SRHLRVSIEP MSGAVILSAT PGLLERFESD ASLDRSTIDD LVARVSRLRC
IAAIEELESN VRILGFETVS PKGLRNDIRK VFPANVLRFS LFWHPLWERN WVVAATSSIT
SDNWWVVRLR RSSEVATDFS VSDTSVPLCS GHSMSDTFLA TSHQTRSSSF PDLGYCLSGM
VAIYANVSYL SDLHSVEFHP PLCALKVESD LQIPDIFIRY QVSNLPRALQ LVLPAGLKRK
NLLKDTVRLA FHGIDRHKNS AIFVAYGNLV GPWTDLCTLI SKSDSSLVFK QGGSGFALRL
LAPAGRPVIV QLFKSLQTLE CTLSILDFLR QRRLTPQSLS LTHIAFAYGP GRDLSATIEM
GLSEVPSSAE LDPVRVLART DPLLCLTLGI RFKHPNPHRR VQGSLAAILN HASNEAGLDF
VTEVLSFTLP LMRALEQITS NASRQEPFRL QVIVRNAYTF LLHYTYQGFR FQLTTRQHSG
QLTWVLRELS SPEAGPGHDQ FKARLRGTLY HSKGNGWKGL GNGVVADAEG VSNVIRALDG
CFTGAQHNTW LPRETKSEQD YSTQPAPENQ SQTGAPSQAG MANDTKMTAN FVNDKSLQRN
PVVSNAADVI TID
