MED14_ASPNC
ID MED14_ASPNC Reviewed; 1114 AA.
AC A2QFK0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE AltName: Full=Mediator complex subunit 14;
GN Name=rgr1; Synonyms=med14; ORFNames=An02g14820;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAK48911.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AM270040; CAK48911.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001400611.2; XM_001400574.2.
DR AlphaFoldDB; A2QFK0; -.
DR PaxDb; A2QFK0; -.
DR EnsemblFungi; CAK48911; CAK48911; An02g14820.
DR GeneID; 4980021; -.
DR KEGG; ang:ANI_1_3362024; -.
DR Proteomes; UP000006706; Chromosome 4R.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR013947; Mediator_Med14.
DR PANTHER; PTHR12809; PTHR12809; 1.
DR Pfam; PF08638; Med14; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1114
FT /note="Mediator of RNA polymerase II transcription subunit
FT 14"
FT /id="PRO_0000304594"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 123843 MW; 7422CBDC9FAFC3A9 CRC64;
MPGVVMDNAN IGGLRHGPGN TYPQDGLSHS RGEVAQFNGA NAQDGPVHVN GVEKNASQSR
SVEAIPSNHA SRVTKGPPEL PHITQGFFPF AKLVNRSVQQ CWNDLSDLIT EMAEMQVNSH
GIHPSTAPTT GKSPGNQSPG NIRKKLRILE FSHAKRAEFI KLLVLSQWSR QAADVSKLID
IQNFIRTRHQ AYTNALQWVG DMKRDLVQAQ VANPDLKTAL EVLSRGKVAS MSDLGYKPPR
RLTVRGTLRK LQKINRLIGA RLVVQDEIPP PFKSYRVHDG RVTFAVPGEF ELDLSIGEEN
ENSQFFFVDI RFLFSPSPPI LKGRLLNELE MTINDVLQNS GLTGCFDLLH NLVLTNKINI
LFKQATELAR SSWSDGLRVE LLHRTLVVQY WTLKPGTKSW LEIGIKSGHR KSDSESPGLP
SLKFRWVRDG GEVPCEDIAF DAKNLSMETV LRSVIALHVS HTLSSAYCKI RQSSLFSTGF
LSLRAHLTRT EPGDCQLDVQ LTETRHLQVS IEPMSGVSIL SAKPTVSDRF DMERNPERSS
VEDIVSRVAR IRCNAAIEEI ESKVKMLGFE PLNPRAWKLD IRRIFPPNFL RFTLFSHQLW
GRSWIVAATS SMDGDSWWVV QLRPTLPAKG PPIPHANGYG QPILRSAQVV TDSFFPARYD
IDDAYLANLG HSLSGILAIQ SNARYLSDLQ SIKFHPPPHK LKIEPDLRVP DILVRYDVST
LPSVFRVAMP AKAKKKSLIR DTIRLAFHGV DPREKCAIMV AYGNLVDSTA TLCPLISSWD
RSLVFQKGGT GFAMRLLAPA GHPVIVSLLE NLQRLECVLS ILETLQRKKV EIRTFSLSSI
SFIYGSERDL AASLNIHLSR NESLMKLSPT DLASRREFLF GLRLGIQFGL QNPHRRIQES
LASSLNRSPT EAGLETVVEL LTLTLPLMRA LDQLMANPSH SGPLRLHVTV RNAKTYQLHY
PGDEARFQLV AASHQNRLVW VLKDANSQGN SKNDDSITAR LRQTLYTSKG DGWKGLETGV
VAEVDQVGNL LRELEKCFVA SRADRADPKH KPTDYAANHT GLNNPEISAL AIKKGTTDGA
KLSLSDSLTT LPNDKGNLSQ ADTAAQKEDI IMID
