ID   MED14_ASPOR             Reviewed;        1107 AA.
AC   Q2UMJ1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=rgr1; Synonyms=med14; ORFNames=AO090001000735;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE57224.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP007154; BAE57224.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001819226.2; XM_001819174.2.
DR   AlphaFoldDB; Q2UMJ1; -.
DR   STRING; 510516.Q2UMJ1; -.
DR   PRIDE; Q2UMJ1; -.
DR   EnsemblFungi; BAE57224; BAE57224; AO090001000735.
DR   GeneID; 5991197; -.
DR   KEGG; aor:AO090001000735; -.
DR   VEuPathDB; FungiDB:AO090001000735; -.
DR   OMA; FAHAKRA; -.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1107
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304595"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1081..1107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1081..1101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1107 AA;  123487 MW;  4D2A0F1192122D16 CRC64;
     MPGVVMDNTN IGGAGQGSAI HDSRNGMPSL TPNINRNSAF GDSHVGRVHI NGMTKNAVDP
     SQAEDASTVN IKSTKSMELP ELPHITQGFF PFSKLISRSV QQSWNDLSDL ITEMADIKVS
     PQEQNSLQLP ASGKSFGNQS PENLRKKARI LDFAHAKRAE FIKLLVLSQW SRQAADVSKL
     IDLQNFIRTR HQAYMGALQG IGDMKRDLVQ AQVANPDLTT ALEVLSKGKV SSMSDLGYKP
     PRSLTGKDTL KRLQKINRII SVRLALYDSV PRAFHSYSIH DGRVTFVVPN EFELDLSIGQ
     EDESSQLYFV DIRFLFNPSS PNLKGRIFNE FDVKINDALR NNGLSGCFDL LHSLVLTNKI
     NILFKQAMEL ARGLWYDVLR VELLHRTLVV HYWTQKAGAK SWLEIGIKSG RICGENDSYR
     HPNLGLRWIR DGQEVDSEEI EFNTKSLSME SILRSVIALH ISHILSSAYC IISESLLYSA
     GRLSLQAQLT RTEPGDCGLT IQLTESRHLS VSIEPMSGAS IISATPSAQE RLDNDRSSDK
     SSAEDIAARV ARLRCMAAID EIESNVKMLG FETVNPRSLK IDFRRLFPNN VLRFSFFWHH
     LWERNWIVAA TSSMDGDNWW VVQLQTTTTA ESHSVFDAST HISSTLRSAQ AISGSFFHVN
     QNIGYPSFAD LGHYLSGILA VHTNARYLAD LQTVDFYPPL QRLVIEPNLQ VPEIFMRYEA
     ANIPEVFRIA LPSGLKSRVR TKGTIRLAFH GVDPCKKVAT IVAYGNLLIP IKAFSALNST
     RDHSLVFQKR GTGFAIRLLA PPGRPVIPKL MENLQRLDCI LSIFECLQRK KMETRSLSLS
     HVTFAYGPEK DLLATLKIET SMPSSSMELD PIFLASRTKS LFHLRLGLSF EFPNPHRRIQ
     KSIESTLNHS TTDAGLDTVA ELLLLTLPLM RALDQILMNP SNRQPLRVQV TVRNAKTFQI
     HYPGQSFRFQ LVATHHLSHM VWILKELSSP KERSSQDQLK LRLRERLYNS KGDGWRGLGN
     GVVAETGKVG NLLTELDRCF EASSTPGLTP EVKASGSKSF SQQLTAENGN VEGTLSESAT
     LIPTPNATST RHKTGDTTQN ADIIMID