ID   MED14_ASPTN             Reviewed;        1103 AA.
AC   Q0CL23;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=rgr1; Synonyms=med14; ORFNames=ATEG_05611;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU34680.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CH476600; EAU34680.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001214789.1; XM_001214789.1.
DR   AlphaFoldDB; Q0CL23; -.
DR   STRING; 341663.Q0CL23; -.
DR   PRIDE; Q0CL23; -.
DR   EnsemblFungi; EAU34680; EAU34680; ATEG_05611.
DR   GeneID; 4320791; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1103
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304596"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1054..1103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1103 AA;  121855 MW;  603F728F1558EEA5 CRC64;
     MPGVIMDEPN VGGHPKGPSV PDSSRNGIPP LSGSDGAHGV SSAHNDGANR LNGSAKGIDG
     YKQNVDSSTT KIDFVGLRQP PELPHITQGF FPFSKLVNRS VQQCWNELSE LITELAEVQV
     PPQDSGPLPG APNGKPLGNQ SEQNLQKKLR LLDFAHSKRA EFIKLLVLSQ WSRQAADVSR
     LIDIQNFIRI RHQAYAGALQ CIGDMKRDLV QAQVGNPDLK TALEVLAKGK VVSMPTLGYK
     PPRPLTAKGA LKRLQKINRL ISARLVLSDS VPTPFQTYRV HDGRVTFIVP DEFELDLSIG
     AEDETSQFYF VDIRFLFTPS SPIPKGRIFN ELDMRINDTL RTKGLAGCFD LLHGLVLTTK
     INALFKQAAE LARGLWSDTL RVELLHRTLV LQYWTLRPGP KSWLEIGIKS GRRSSENSIN
     GLPSIGLRWI RDGQEVDSRD IEFDSKNLSM ECILRSVIAL HTSHILSSAF EKLSKHSLFS
     TGALSLRGRL SRTEPGACQL DVQLTRSRHL RVSVEPMSGT SILSTTPSTL ERSDVDRNTD
     KPFADEIVSR VARLRCISAI EEVESNAKLL GFQVVNPRSL KLDFRRHFPA NILRFSFFWH
     RSWERNWVLA ATSSMDGDSW WVVQLQPAVP SESALPFDAN SGISAPRSAQ IVCNTFFPAP
     QHNMKSPFAD MGHSLYGILT MQANARYLAD LQSISFHPPL PQLVIEASLQ VPDILIHYQA
     LKLPRAFQVA MPAELARRSF IKDTIRLAFS GVDPHEKAAV LVAYGELLSP PNDVGALVSK
     QDRSLVLHHG GNKFAIRLLT AAGRSAMCEL LESLQRLECA LSILETLRRK KMQPQSLSLS
     RVGFLYGPRA ELSANIDINL TTSSTHTIID PLHLVTQEKP LFQLRLGIAF DYPNPHRRMQ
     GSFTSLLNNA GATSSLGTVT GLLSVTLPLM QALDGLMANP SHKDPLRVQV IARNAKTFQI
     HYPMQKVRFQ LLITQRPNSL VWVLREAGGL QGRSSEDQLK SRLKERLYHS KGDGWQGLEN
     GVVATIDKVG NLLTELDKCF SGLDDIPILN QSPLETKPIP SKPTMGNTEP AASGNTVQNA
     RLENKSPQKA AATHSNADVI TID