ID   MED14_CAEBR             Reviewed;        1540 AA.
AC   Q61IR6; A8XAD9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 3.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
DE   AltName: Full=Mediator complex subunit rgr-1;
GN   Name=rgr-1; ORFNames=CBG10098;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601459; CAP29607.3; -; Genomic_DNA.
DR   AlphaFoldDB; Q61IR6; -.
DR   SMR; Q61IR6; -.
DR   STRING; 6238.CBG10098; -.
DR   WormBase; CBG10098a; CBP45809; WBGene00031576; Cbr-rgr-1.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_261308_0_0_1; -.
DR   InParanoid; Q61IR6; -.
DR   OMA; KITPREQ; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1540
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304590"
FT   REGION          41..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1382..1540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1416..1450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1487..1501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1540 AA;  173906 MW;  EFB11859E2D4D034 CRC64;
     MNNIPIKMSL DFFVFCFGQS EKLSSQLRGA LAADSPAMAA RSSLDPTGSV LSLDESSGIS
     DHEGFSSAEQ DNFSNRKPED QAKNSSDSEE DVEAKNPLPD VPPGCGPPTI PLNVLLDFSI
     QHVYHEITVL AELMQRKTND QGEQERKMSL VHFAHATRSQ FLKLVALVKW IRVSKRMDVC
     YSIDYLLDLQ SQYFIDTADR LVAMTRGDLE LARLPEYHIA PAIDVLVLGT YNRMPSKIKE
     AFIPPAKITP REQKQVCARL NQLIETRLSR LSSGIPPNYK EIHVANGIAT LLVPGEFEIK
     ITLLGETEMT KWSLLNIKIL VEDYELGMGL PLVHNLQLNQ IHGVLQSRMD VAVNPVKEAF
     FNLHSFCVSL QLDVLYCQTS RMAAGRLREN IVIEKYDPKE RMLVVGYWVK RSKNKRLTVG
     QVKIDAQYRV QIYEDKDDKL GGLKVRHFPH APRLGTIDCA SGMLSMDRML SETFAVRCSE
     RLMRLRRILE AAEPLLEVRM TGSNVPTLSL SLLPDTSSNE EMLTVSVNSF CGKVICNINV
     LNSENDDLVA FAKALYSSRC SGQTIRDYLQ KLRTSLVIER YRRSVAALPV REIKETELLP
     FVKVMLREAP KQRIILQYTR SENYYLIVGF IPEGEDVVTT KLQLLECDDE RAQFIPLDND
     TEVFQTAVAD AVEQGTMRFK NCDDRISLLE ECSREQRLAF AIITVEDRIT YMYLATELQK
     KGVGVELRRD DAHVPGGLAL HITNVKTVVP FDAAEFFKCC VRSCLRLDNR TRHTFQFEMC
     FENIPLVRDV PHGLAHRREG DKDTTWVQEI SQVNQMTPEK LVEGIIHRLM RYLYMYKVVH
     QFSLAYEQYF KQWCNVEVYT FHKLVVSYGE NRDMLMVLAF NVKSQNPGSQ EDYFLMNFGQ
     TMPHSQFNTP EVDWLKKPRY NPHAMMSQLL RDELKKNNDL IYIMHYLCET IRPFMVIGKF
     GRIRFQSQKS LSQLIGPEVF FPYRLKYHLA VLDLTTLRLM RGNVILEIKM LEGQKVAVRD
     VSRYRARCAG LYQLFSNIDP VTTEIMCEEL EIPESDNKIN AGPTMWKPEQ FMDAVDVPHE
     DDPRMKITSL PILMTHDTII KACDFQEIDG HVTCPLDEYL YSISYLQRAL LTLERMSPRA
     QQGPANNLFS GYVTVVDAKP DYVRFKATQL NGDGTNATAM VYYKIYLCPE AMTLKIHIEY
     DEGTNSEATP KNLTALSTYF EKVVFRCGDE YALQSYVVMT RVTSFGATAS IANLMNAQMD
     ISLESKCCLQ LSLTYNNTTS KKLAPATKVD QQLNNMIINV IISQSRKADS FSVLRFIYRI
     KEWVICYSCL KKSEVNFVTV PSELNKQLID DVNTEVKTTG KCAIWALVSL VSDRFRSGEW
     NPSNQDEPII STVAPPAPQQ YVNPPSVAPG SIAPPGSGAP QQQQHQQQPP PSVMQPGSMM
     GPQSVNAHQY GMHRQMGGPP SMQMNPSSVG PPPGSVGMPG SVGPGSMMNP GSHQQHMMNP
     GSVGPGSVGG PGSVNPGSVG YPPWGPGGQQ YHHHMQYPPQ