MED14_CANAL
ID MED14_CANAL Reviewed; 1261 AA.
AC Q5AG31; A0A1D8PNN0; Q5AGG6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 3.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE AltName: Full=Mediator complex subunit 14;
GN Name=MED14; Synonyms=RGR1; OrderedLocusNames=CAALFM_C503160WA;
GN ORFNames=CaO19.11825, CaO19.4348;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC {ECO:0000305}.
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DR EMBL; CP017627; AOW29736.1; -; Genomic_DNA.
DR RefSeq; XP_720653.2; XM_715560.2.
DR AlphaFoldDB; Q5AG31; -.
DR BioGRID; 1220766; 3.
DR STRING; 237561.Q5AG31; -.
DR PRIDE; Q5AG31; -.
DR GeneID; 3637800; -.
DR KEGG; cal:CAALFM_C503160WA; -.
DR CGD; CAL0000182774; MED14.
DR VEuPathDB; FungiDB:C5_03160W_A; -.
DR eggNOG; KOG1875; Eukaryota.
DR HOGENOM; CLU_283151_0_0_1; -.
DR InParanoid; Q5AG31; -.
DR OrthoDB; 1215335at2759; -.
DR PRO; PR:Q5AG31; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR013947; Mediator_Med14.
DR PANTHER; PTHR12809; PTHR12809; 1.
DR Pfam; PF08638; Med14; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1261
FT /note="Mediator of RNA polymerase II transcription subunit
FT 14"
FT /id="PRO_0000304597"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..433
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 146559 MW; 7A796D77FFCC52D1 CRC64;
MPNGKQQHEV TESSSPPEIP HITANMIPLS NIIKYYTQEA YKQLTTAIEN LSMNVNEESD
IKRKKYFLNV IINLRQDFIK VYTLIKWASI SKDVSKFIDL LNWFRIQEFH FENLIFQLNA
LTGYNAAKLP NSDIITALEV LYHGRPKLPS YNYIKSDNLS PQKILETLND LNLVLMTRFA
LMDNIPKRFD YEIKDGRAYI RVSNEFEVSI TVGNDLIIDN PEEYYKSPFY FIDFKFLFGA
NPESGLITFN DDKISTKLPT SSHKKLEKLV NQTLLTRGLQ GLYELLHKYS NSFKIYLLAK
QFQTLLINSR WRGNFQINYQ TNKSLIVINY WSQHYLSRNW KSFIELGIDS HSNLNYRWFK
NGQYCFGDQG NNELDKIFHL QRRNSNNGVT TSSNTISTSA MIAGIRRSTE LSNETAIVDD
NDNDNDDTNN TGETENEDLN VDLILNVVVN QHAKSIMSEI YSQLLTRFSE TDVSMVSPHQ
LLLQISPKKS TVFAINPLTG FFYFIDPTPI QTYITKKINS PPPTLSQVSI KQSFIPESDM
ISYVIDQIIQ LRLEVFNKEV NTKLATTAWI NNGIIKLSDH ELSKLTQFLI QNEEQEGDDN
EEDSSTNTRL DSVLQSFKVQ FYRRKNWPSS WFLINMISGV TTKSFWWVAR IKSISGDWKI
QWAQIIKFHG DNAKQELSPN ESKVFDKPKR TVDCSIESEQ LNFEFFKTLS TLSSNLILDH
MILEELQVRS IKFIKLDWET IDDNKIFSKF KQNHDISLKR KNSHNINIDV NVDVADNTST
TTNTKYIRAP KLKYESMFLI YNDKLLPIYN SATILFLKIE LVESNKMYLK LFGNLRNLQI
KNTSEDIQKL HLNIDEANQY FEIDNTVDLS TVINEPKTLL LNLIFNTLNK LNSLIKILDQ
LNKSNVTVLD NSMDNITINI KDKYNDNNDK LIIIKLPEQA TDSIQLLMKN GSTTTTDEID
LRNNNILEFE LILKFLNQYL RESKSNNHNR QQISIIKIIQ YLTEINPILQ STKAINQQLA
ELKRINSTNN NNNNAKRRSI LKLSNGLYKL YFNLNIISLT HLQLVFFMNS NTGSNLKKIQ
RDKIMINLSL IKFDRFSKPN GNFQDSTNGH LIKISFKDSL INENLKFKNL FEIIFKNINE
LLITKSKQIK SLNQTENQQQ QQPLKQEDNS DSAIIKKESQ SIEDDLLDFG EYDNDIKPQQ
QEPQQNEKEN SKTTSKENET VRPDDILIKL NYDYLLSMNN LQLMINEITK SCFQYLQQQQ
E
