ID   MED14_CANGA             Reviewed;        1037 AA.
AC   Q6FKA5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=RGR1; Synonyms=MED14; OrderedLocusNames=CAGL0L13112g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380958; CAG62313.1; -; Genomic_DNA.
DR   RefSeq; XP_449339.1; XM_449339.1.
DR   AlphaFoldDB; Q6FKA5; -.
DR   SMR; Q6FKA5; -.
DR   STRING; 5478.XP_449339.1; -.
DR   EnsemblFungi; CAG62313; CAG62313; CAGL0L13112g.
DR   GeneID; 2890589; -.
DR   KEGG; cgr:CAGL0L13112g; -.
DR   CGD; CAL0135684; RGR1.
DR   VEuPathDB; FungiDB:CAGL0L13112g; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_286680_0_0_1; -.
DR   InParanoid; Q6FKA5; -.
DR   OMA; MIDLLNW; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0001093; F:TFIIB-class transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1037
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304598"
SQ   SEQUENCE   1037 AA;  119213 MW;  D974201B7CDDCC6F CRC64;
     MNGTRAAPGV TPSEVAMNGK NEMEVVEQAP IPKTNANIGL KSPVNTVEDV NQEDSTNSPP
     PIPHVEINQM PLSMIIRNLT VYTVKEISQY MKTTVHMNTA DTSTARKMRF LNLLIFIRNQ
     FLKLYVLIKW CRTIKENNFN IMIDLLNWFR GTNMTVNNCI WALKSTLEST TNAKLPNVDL
     VTALEVLTLG RPNLPTHDFK LSGENNEYET VNGQLRIPTK LIMQRLKDLN IIVMIKISSI
     DIPKQFNNYE IRDGRVYITV PGEFEIQLST IDRHSPFFFV DFKLLFAGTD SLFNKPRLEK
     IINDVLLRNK KPLYSLYSLL HRYVLTLQLY MIHLELLNLE NDGKFSGGNL VHSYNAKKSL
     IVMKYWRNGK LGNKTKIIIG VDRKSEDLVL KWDNENAKQS MHMPLVYTHV VGNVEAILDE
     IMFNHSRLIR ADLLSRGVFQ EDEEDPSVLL FQLPTTCLST APIQLKIDLV SGVFYFKNPS
     PLLLEYVSQI NRAETPEDLT SVLQRLKLDK IVHIIRNMFD KTGWVCSKVI KLDNPIATSV
     NSEEIKTNLL QNDMFIRLAS WPVNWYLILT IVSSNSSCII EKRIGKIIST SGKWKVQYLD
     TTNVLSLKLE SITYKKIISL QKSTLNRIIN HTLIDSLNHL KTRNKVCSPD LIVNSLPKHL
     LEDEVDDKVP HSIENYHHIS LITIELESFL EGSKALSGIL ESTMFLRMDY KKFEIRLYGK
     FKRSTMAFHC QCDDLLINFV EREPLAFYLA ETFTNLNEIV QYLTLFRQKL MQLVVLTDVV
     ERLHKNFASD HFKIISLKPN EVTFKYLKSS TDDKDCTINI ITNEQTIKNL TVKLSDKNPQ
     HIIQPFIDNQ QFEYQFIFSY LQFTSPLFCC LKEILDESNK EERLENAKEE SDSTRTSTSI
     TLGLHNLSEY QLVYFNPELG YKITLILELK EVSINGKKKI QFYVHFSQDE HITTKSSAYP
     LIHQVRNEIF MLEMKKRDGT PSLIKLDNTR NVIRLGNGIS CDSDSIVEVL MSINKILLGD
     SKSAPQITTV PPTNKTI