ID   MED14_CHAGB             Reviewed;        1178 AA.
AC   Q2HDU8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=RGR1; Synonyms=MED14; ORFNames=CHGG_01606;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; CH408029; EAQ93371.1; -; Genomic_DNA.
DR   RefSeq; XP_001220827.1; XM_001220826.1.
DR   AlphaFoldDB; Q2HDU8; -.
DR   STRING; 38033.XP_001220827.1; -.
DR   PRIDE; Q2HDU8; -.
DR   EnsemblFungi; EAQ93371; EAQ93371; CHGG_01606.
DR   GeneID; 4386331; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_003573_1_0_1; -.
DR   InParanoid; Q2HDU8; -.
DR   OMA; FAHAKRA; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1178
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304599"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1064..1178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1067..1081
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1082..1109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1119..1169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1178 AA;  133116 MW;  8ED31AA0F4D4CA44 CRC64;
     MDNSVHNNSN TTHPDKSRAS IVNGVREERV SLSTEPPAGV KGGDNGPITV GDYNKLESRL
     QGAGMEDSVD ELQHITDDVM PLSLLLSRLA QFSHLKLQEL ILDLASKPLP ENTLNGNAKG
     SMNSSINGNV NAGVNGVPKL PSPALEDTSP ESLNKKTMIL KFIQDLHSRW VKALVITEWA
     RNADEVGKLI DLRTHLAAKL ELYNRAFWNM VNLKHEMAFA KVPSPDLKTA LEVLSTGAVH
     WMPDFGYLPK PPLTTQETLH WLNEIEVVLH MRLQLHEYEQ IPEPWKEYKI DNGRVTFTVP
     GEFEVDLTIS DEDFDKQFWF LDYRTIFSPS PSKLSDGARG FIEARVNTIL ETEGLLGCYK
     YLHELTLTTK IGEFARQAVE LSRTGLWTQT LRVERLNRAL GIQYWSQSLH TQDSQSWILL
     GVHSGKSSDG ADDPSSPSRL MLQWFRDGKE VKDADIPLDT DTISTEKLLM TVISRHIKYL
     LSSIYNSLSS KPRYAQKRGR LSLRISDPPH LDCALTMQTL GADHAVLGIG PWSGNFFFAD
     RPPFGVGWAN KINTLRNPVT EAPVVLEQLR WYHMTLHLRT LPKPADWKVL PKAPVPLDEV
     KRVVYSRAST TREPFHAIFL RNSRWTPQWF AMMSLSLGGD RWWTAEGHGI PGLRINIFTE
     LSITPTDLLL PSSPLFSKLT QHATNIMDQI HDFRVLHQQH IQYTARKASP DGHRTTVVLS
     ADMLPLQPDP DGTTQPTWAG RFIQLDYKGP APITPSEYRE SLADPKSVRR QPTRQKVMIE
     ATVGVLHPTK FRLLRHRLDR DVLYDRRLGH FTLRFQPASG AGIIPLLRSR VQSLDRLVDI
     VDALHLRGKQ ISPKKITLRE IVFSYGNGSP TMSLSNPRPK FGGNKQRSWE VRLNLAAEQG
     VDVILEAGNP HLRAIDYLRS AANSVHLKKL PAWFVFTLPL YEALEQLHDS WDAILAKDLG
     TCYVFHKSLD WLTIRFALSG AKNRLVQLDI RPRDRNGHIN WHISRAKTDP NINNENDEFN
     KILKQRVWSI SGNGFKGLGN SATAQWDHGI GPLLAVINEA LQSLAGTPPP PQVPTQIQQP
     QQPSPHPQQA QVQEQRQQPQ QQQQANPLQG AAVPGRFPHQ LQQGQQLSYQ QQARLQQQQR
     QQQQQQQQQQ HMHNQNQAQQ AQQRAAMNDI NTPVVVLD