ID   MED14_COCIM             Reviewed;        1105 AA.
AC   Q1DZL3; J3KDK0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=RGR1; Synonyms=MED14; ORFNames=CIMG_04250;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; GG704916; EAS33226.3; -; Genomic_DNA.
DR   RefSeq; XP_001244809.2; XM_001244808.2.
DR   AlphaFoldDB; Q1DZL3; -.
DR   STRING; 246410.Q1DZL3; -.
DR   EnsemblFungi; EAS33226; EAS33226; CIMG_04250.
DR   GeneID; 4562608; -.
DR   KEGG; cim:CIMG_04250; -.
DR   VEuPathDB; FungiDB:CIMG_04250; -.
DR   InParanoid; Q1DZL3; -.
DR   OMA; FAHAKRA; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1105
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304600"
FT   REGION          28..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1105 AA;  124583 MW;  2F749CE8FB8FB8DC CRC64;
     MPGLAMDGPS AMASRATVAD MHYDPASASQ QANGGIYRNG IGKKSHSPVD GLHDSHIGCL
     HELPPELSHI TLGFFPFNNL ISRVVQQSWN DLNELLNEMG SSQAYQTGIS SQLSATKNGM
     SEKFRGDQAT ENSLKKLRIL EFTHSRRAEF IKLLVLSQWS RQANEVSRLI DIQAFIRMRS
     GFYEAALFHI GNMKQNLIVA QLANPDLKTA SHVLSAGKID ALHGLEFLSP RPLAPSQVLR
     LLRGINKLID MRLALHDHVP DSLQNYFVHD GRVTFIVPNE FEIDLSVASA APSAQFFLVD
     MKFLFFPSSL PKGRLRSIVD HQVNSTLMNA GLVGCFNLLH NLILTHKITI LFKQAIDLAR
     TYWSEHLRVE LFHRTLVLQY WSKKPGGKSW IEIGVHSGLK GSPQSTGTTT SFLQLRWFRD
     NEEVSATDID FNLTFLSAKS ILFSAISLHI THILRTAFEA LRQNRLYCLG GLYIGMSASS
     KEPGDCYLEL QMTQTSHLDI MVEAVSGDTV LRVAPSPITR YDTEIIVDRG SVEDIVERVS
     RLRCVSALEE VERYAKAVGW MPLNLRHVNL ESLKRIFPPS ALRSMLLFRA KCWEPSWLAV
     FTSAMDGDNW WIVQLQTQNP PALQSHWRLL EAQRAKLITG WFTGWLGRLH NASFSSLLSA
     LSGMIMVQCN VDFLNEIGAI HFFPPPKDLL LQPCLRVPSI YLRLRHDDFP SQFRTIFSGG
     SPRRSFIDET FRISYKGIDQ QSGHAITMVY GRLMTDIDMF GALYAKSVQD IAFQPKGRGF
     AILFRTPVGT PIIAPLLERL QQMNNIAFVV ESMKSQGFQP HSLSPLRIKF SYPTQGELRG
     SIKFIYHDQG SHFESKLLFP ATTTKPILHP RIGIDFNYQN PHRRITESLS TILNSHKDGM
     SLVLELINIT LPLLVTLERI CAEEYIDNAW CFRAQYTARS ARLYQIRYPF LRYRFNVSAS
     QRKSYVVWVI QNSTPGPERS KHPSLELRLK DQIYNSQGDG WRGINQGAMA YSANVSRLVF
     DLHQLMKSYI SQMAKSNQRG EPTDSSPSAG CEFGRYLPKN ENKKGHIQTT TAPTLEHAYG
     NSNMVVQSVR QGEAAARDVD VIAID