ID   MED14_DEBHA             Reviewed;        1123 AA.
AC   Q6BPK1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=RGR1; Synonyms=MED14; OrderedLocusNames=DEHA2E12958g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382137; CAG88110.2; -; Genomic_DNA.
DR   RefSeq; XP_459869.2; XM_459869.1.
DR   AlphaFoldDB; Q6BPK1; -.
DR   STRING; 4959.XP_459869.2; -.
DR   PRIDE; Q6BPK1; -.
DR   EnsemblFungi; CAG88110; CAG88110; DEHA2E12958g.
DR   GeneID; 2902653; -.
DR   KEGG; dha:DEHA2E12958g; -.
DR   VEuPathDB; FungiDB:DEHA2E12958g; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_283151_0_0_1; -.
DR   InParanoid; Q6BPK1; -.
DR   OMA; SSWFLIN; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1123
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304601"
FT   REGION          450..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..484
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1123 AA;  130809 MW;  502C20539EC5A231 CRC64;
     MSLLSIDDIF IPTSDLLNHS HNNKRLNYNQ AKQTLLLNMN GSYPSSNNPI SNGEPCDAKS
     NHLGGEMHNG VGSKLENGIL KKAPDIPHIT NNIIPLSNVL KFYTQEAYKQ LTTAIENLSS
     TKDTENDSSR KKFFLNLIIS LRQDFIKIYT LVKWASSSKD ISKLIDLLNW FRSQDFYFEQ
     LGYGLNELNR YSGAKLPNSD IITSLEVFIK KRPQLPSYNL ISTPPISSEK TLEVLKDLNL
     TLMTRMALIN NLPKRFINNY EIRDGRVYFT IQNEFQVSVT VGNDLIIEQE DDYYKSPFYF
     IDFKFLFGIN PETALITHKD NKIITKLPKS SFQNLEKIVN TVLLNSGLGG LYDLLHKYSI
     SFKLYLIARQ LKDISINSKW RNNIQFKYQN GKSLILINYW SSHYLSRNWK SFIELGIDKN
     YNLNFRWFKN GTYELNHGIS GIFDRNNIKK QSDASDEQQN NIEPNEESLE DLREDNNEDE
     SEPQDLSVDL ILNIIVNKHS EMLMDKIYET IVKRLSDQEE YCSFISCHQL LLKLTPNKSV
     VFAINPLTGF FYFIDPSPIQ NQVTKKINTQ SSNHKNKPFF SENDMVENIV NQLIQLKLEM
     FNKEINNKLI TSGWINNEII KLNDYETIKL SNFLNGDNFN NSNYNKIQFY RCKNWPLSWF
     LSNLVSGDNF RTFWWVARIK SIKGEWKIQW VQQLKFDQEM ETSDELTLDY KFFNNLSSLC
     SNMIIDHMIL EELQTKKIQY IQKQSKEKAA ELLNKFQIDE VKEENIKPEE TNNPFVYESI
     IMLYNDNRLL PVSNSSTSLF LKIKLITLNN STQMKLKLFG NLRNIPNTLA ETFNQLNLHI
     SKSQNYFEIN DIVNLSNKIN DSSIKETRLL DSILLKLNVL NELIKVLYQL DQNNIEIVNS
     SIDSIQIKID EESNNLTIKL PEMDEKFSLL SSNTESNEMK LIISYLNKYL SMTSKVQENE
     IIGIIKYFKE ITPIVKTIKS VRATLDEKNK MKLSNGLSKL NFDVEFQNLN LIQFVYFLNH
     TNVNSNKKIL KDKIVIKLNF MRNRFNKQDR LLLKLSMKDN LNSRNLKYKK LFELIYKGIS
     EVDTTNGSKI TKLNYDFIVD SSLINELMIK ITDAFILFLS DNA