ID   MED14_EMENI             Reviewed;        1103 AA.
AC   Q5AW92; C8VBB2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=rgr1; Synonyms=med14; ORFNames=AN7438;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CBF79382.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CBF79382.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=EAA62018.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAA62018.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AACD01000129; EAA62018.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001304; CBF79382.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_680707.1; XM_675615.1.
DR   AlphaFoldDB; Q5AW92; -.
DR   STRING; 162425.CADANIAP00000529; -.
DR   EnsemblFungi; EAA62018; EAA62018; AN7438.2.
DR   GeneID; 2869472; -.
DR   KEGG; ani:AN7438.2; -.
DR   VEuPathDB; FungiDB:AN7438; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_003573_1_1_1; -.
DR   InParanoid; Q5AW92; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1103
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304602"
FT   REGION          22..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1043..1067
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1103 AA;  123042 MW;  3D801C8936AD117D CRC64;
     MPGVIMNQDN INGRGLGLHD QLNGVSSAPA GSSQLGNPVG LHNGSLPTNG VQHPDSRGSD
     ENYRTKMMLS ASGDPPELQH IVQGFFPLAK LLNRSAQQCW NDLADLVAEL AEIQVPSHDS
     NFSPISPNTK VLGNQSPENV RKKLRALEFA QKKRGEFIKL LVLSQWSRQA ADVSRLIDIQ
     NFIRTQHQAY AGALQCMGDM KRDLVRAQVA NPDLNTALEV LLRGEVVSMP DLGYRPPKPL
     TPKSTLKKMR KINRVISTRL ALHDDIPLAF QKYRVHDGRV TFVVPGEFEL DLSIGEEDVT
     SQFFFVDIRF LFSPSPSIPA GRMLSELDIK INDTLRNGGL SECFNWLHNL ILTNKINILA
     RQASELSRSL WSNVLRSELL HRTLVLQYWA SKPNTKSWLE IGIRRGPRES TIGGMRPPSL
     GLRWIRDGQE VNSDDVEFDT DSLSVDRLLR SAIALHISHI LSSAFRRISE KLLYSNGSLS
     LHAYLTRTEP GDCQLDVQLT ASRRLRVAIE PLSGAIVLAA TPNTLERVDT DRNMDRSTID
     DIVSRVGRLR CAAAIEEVES QVKMLGFISV SPRNVRIDAR SLFPANVLRF SFFWHHHWER
     SWLLAATSSM DGDKWWVVQT PSADSVTINR SLDAAVHHAS SAVRSAQVIC NLLLPAEQPD
     YSSLADLGHC LSGFLAIYAN ARFLQDLQFI KIWPHLEHLR IGPGLQVPDL NIEYEATKLP
     EALRVALPAG FKRKTFVKKT IRLAFHGIDR CRKVAIMVAY GNLSTSFPAL GDLVAEDDHS
     LVLQKTGTGF ALRLLASPGY PVVVALLESL QRLECVLSVY EILRRKKMDA RFLSLSRLGF
     AYGPNKELLA QLDIGETQPQ LPTEMDPLKL AFRTGHLFHY RLSISFDHSN PHRRIQGPLA
     SNLNRPTAEA GLDTLTEILS FTLPLMQALD RFMANPSRNE SSIVHVTVRN ATSFQIHYPY
     EKCRLRLVAH QHQNQPVWVL RDVLSFQDGS CEPEFKHKLQ ERLYNSKGTG WRGLGNGVIA
     EPDHIGDLLD ELDRCLASTK ANTTPKALDS RTSHDAPAAN NQSPAIRPEK SVEAADMHGG
     FVNRNLQQKA GPASQKTDVI TID