ID   MED14_MAGO7             Reviewed;        1108 AA.
AC   A4R0J9; G4MR81;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=RGR1; Synonyms=MED14; ORFNames=MGG_09925;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; CM001231; EHA57413.1; -; Genomic_DNA.
DR   RefSeq; XP_003710025.1; XM_003709977.1.
DR   AlphaFoldDB; A4R0J9; -.
DR   SMR; A4R0J9; -.
DR   STRING; 318829.MGG_09925T0; -.
DR   EnsemblFungi; MGG_09925T0; MGG_09925T0; MGG_09925.
DR   GeneID; 2680895; -.
DR   KEGG; mgr:MGG_09925; -.
DR   VEuPathDB; FungiDB:MGG_09925; -.
DR   eggNOG; KOG1875; Eukaryota.
DR   HOGENOM; CLU_003573_1_0_1; -.
DR   InParanoid; A4R0J9; -.
DR   OMA; FAHAKRA; -.
DR   OrthoDB; 1215335at2759; -.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1108
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304604"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          35..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1048..1108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1048..1072
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1108 AA;  125413 MW;  D4CC5E31C67F1930 CRC64;
     MAAVMMNGVG PDGAMKPNLD QKLNNHGGDT KAISSSEIVQ QQTPARSLQS DNPLRMNDLP
     DEIVHITENF LSLNQLLSRL AQRSHNELED TIRSLAKKPL PMPPMLNGNA DHNTIEDLSN
     ENLDKKVTLL KFAQEQHAKW VKALVITDWS KKASTLSKLI DLKVHMHTQM EKYDFVLDRM
     MHNKRNLAYA RLPSPDLKTA LEVLANGDAP WMPDLGYIPP PEMSPEDQLK WLEDLDTLLS
     LRLTIDDHDK IPYHFRNYRI GSGRVTFIVK GEFEVDLTIA DDDPEKQYWF IDFRFLFRPA
     PPGLSENLRM YLELKVNEVL GAEGLAGCYK YLHELVLTHK INELRRQAME LSVGRWVDAL
     NVERLNRSLA VQYWTSRYPA KAPNAPKSWI IIGVHSAAPS GGLRATAPTS RLALRWFRDN
     QEVKDIEIPL DEADLSMERI LKDVIGRHTQ QILTLMHTGL RNKPRFVNKE DHLVLELSRK
     QPSESLLTMQ LTKLDSMVVR VDQIGGTFAV QPRTRPMPMA ESNLNTPGRD PVAVIGWVRN
     TFAMEELVRR GKSQGWVVGK PPVKPDDLRN ILSNREQTDA MAWFRKQGWR PQFYVLAHLS
     MSGDQWWLIE LTTPNSNSAA STAGGIRIRT HVQLQFASKQ AIMESPSFFS DLNYFTSAMI
     SKMRDLRELH SRRINHIDQP CIRPGLSSNI RMPTIFIRTS EVLPSLSGKG SLGRWAADEV
     RLSVANVQSS SSTEVDRRGE NRSALSTRMD SRIVIASEAR LRVLDKSKFR QLSSRVDRDV
     AFNHKTGEFV LQLRSELGET MIDKLISRLQ TIERLYEFLG SISRAPRGVQ CETVTLRRVV
     FTYSDLPQPV SEELAALQPP TKRWKVVLDF ADPRTVKLVL EKNNPHIRAV DMLQTLANSP
     RGLERLPFYL PTTLAVYRAL DSISDAWLQL QVSRKGTFEI FTKNIDLATI RYDLPGPQAR
     RLTLDVKLVS RRGELSWHVK RTDAEPNKSN DEFSRVLKEV WNTKSPNWKS LSTSACGPAS
     AGVEELLKGI DKAVRTLLES PPLVLQQQQQ RQPVVQPGQQ PQVQNQANGV MNRGPQRPGL
     PGAGGLGAQM RQKQVPQAPM GNHVVDLT