ID   MED14_YARLI             Reviewed;         901 AA.
AC   Q6C9Z2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 14;
DE   AltName: Full=Mediator complex subunit 14;
GN   Name=RGR1; Synonyms=MED14; OrderedLocusNames=YALI0D07194g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 14 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382130; CAG80708.1; -; Genomic_DNA.
DR   RefSeq; XP_502520.1; XM_502520.1.
DR   AlphaFoldDB; Q6C9Z2; -.
DR   SMR; Q6C9Z2; -.
DR   STRING; 4952.CAG80708; -.
DR   EnsemblFungi; CAG80708; CAG80708; YALI0_D07194g.
DR   GeneID; 2910799; -.
DR   KEGG; yli:YALI0D07194g; -.
DR   VEuPathDB; FungiDB:YALI0_D07194g; -.
DR   HOGENOM; CLU_283151_0_0_1; -.
DR   InParanoid; Q6C9Z2; -.
DR   OMA; FASHRIV; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013947; Mediator_Med14.
DR   PANTHER; PTHR12809; PTHR12809; 1.
DR   Pfam; PF08638; Med14; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..901
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   14"
FT                   /id="PRO_0000304609"
SQ   SEQUENCE   901 AA;  101061 MW;  62ACDA3F501E7486 CRC64;
     MKGSDIPHVE ANYVDLGRAV GTVCDNAHRE LANVLETLPS TPADVAKKQA LLEVLVRARQ
     EFVRTYVLTK WAKVSEDVTK CIDVVAWLHG QRNCFDNLNH MLVGLGRDLG AAKSRNPDLQ
     TAVQVLTRGA PTTFGDHDMA PKKKLKPQTI LRTLRDLNVL LSVQLAQSTD IPPQFKRYKI
     ANGRATFTVA NAFEVDVGIA DDTLDGPFFF IDFRLLFGDR KELPPQTRGM LERAGNSALA
     QRGLSALYSL LMKFALNYKL ALIYKQIMEM SKGLWSGTLR HRFYQERSLI ALEYWVSQHA
     THRPKSTLEI GIFSESDLRI AVRWSRQGEE VPYSEHQIQF GGESTDVASL LEYVTTLHLK
     HIISCVYTKL RALLGDSSDM VSLCSDGHKL RFRLTSLRST VFTVDRLTGK TVLENATSLI
     LSAERSLNEL VSRPDQAASV LFKLRLLSLE NDIRTRACAT GWTAQNVTLS TDEMKTHFGF
     TTRYVLFLRQ PQWPSNWFVV VTVPEDGSLP LWWIAKLRVR KDTAWTAECM DRIHVNQDLD
     SLYDYELLTQ MVTFASHRIV LHPILDELRA AKTPFRLLRS AQHTPVVAID NSALVTSWSH
     SSLLILPEMS AGSMDMKLHV QGRAKTVMNL PSNDSIDFDA STGIYKLTLE GANTPGFSLV
     NKLKERLQQI EQIVSYIELI KDLGLELVTA SMQQIKFKLG DAQVSVDIPS ELNPNITLHL
     SPTDPHNIIH SYLQETLNSS GLRPVVWLLQ TTRNLYTTLQ KLQKTRGGDP EQLEKIISNL
     SISDLETRQK QLQPRLSIVP RSAAFVRLVY PGKMNIDVTL VRHSATLDGV KFFIKESPLE
     LPPPPQPGQP PVAVPRKLQV WNGSVTPDVD VGKAVYLNDG IACEGDNVGK VLEWVDKQIG
     K