MED15_AEDAE
ID MED15_AEDAE Reviewed; 779 AA.
AC Q17BA4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 15;
DE AltName: Full=Mediator complex subunit 15;
GN Name=MED15; ORFNames=AAEL005022;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
CC {ECO:0000305}.
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DR EMBL; CH477324; EAT43542.1; -; Genomic_DNA.
DR RefSeq; XP_001650211.1; XM_001650161.1.
DR AlphaFoldDB; Q17BA4; -.
DR SMR; Q17BA4; -.
DR STRING; 7159.AAEL005022-PA; -.
DR VEuPathDB; VectorBase:AAEL005022; -.
DR eggNOG; KOG4274; Eukaryota.
DR HOGENOM; CLU_011336_0_0_1; -.
DR InParanoid; Q17BA4; -.
DR OMA; CCLDDKR; -.
DR OrthoDB; 1424577at2759; -.
DR PhylomeDB; Q17BA4; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.246.20; -; 1.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR019087; Med15.
DR Pfam; PF09606; Med15; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..779
FT /note="Mediator of RNA polymerase II transcription subunit
FT 15"
FT /id="PRO_0000304666"
FT REGION 70..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 82337 MW; 0822B26A3AB2B37B CRC64;
MAEDNSWKTP SFRQSVVNKI NEAIQQSGMT SSKNGLEMEN HVFQKARNKD EYLGYVARLI
LHVREMNTKN KNQQNPAGGS QDGGNPNQQG GMPDPINALQ TLATQGTRPQ MMGGQMGPGG
PMGNQMGGGN ASNLLNTLNR PQMPMTGGMA NMQGRVGTMG GPNQMGGMMP GQMPQGMPGM
PNQMGGAMGP GGMSGGKIVG QMNPMGQMNP MQMGVSGMPQ GAGQQQPQQP QGQQGGPGGP
NQMNPMGGMG MQVNPGGHMN QNAINQQMNQ VGMSSGGNQM GNLGGNSPMN PGNMGIAPNQ
VIRQQMPPGM NPNQQQLGMA GGQMNQMNQG VGGPGGNLGP VQQQQQPGQV GMAGMGPGGP
GNLQQQNNPQ QQSQGGPNAA PGQMNQVGGP GGNMQAMGNQ GNFVPIGANP MVRKQDMMSG
GQVYPGGVVR SVTPNQFLRQ SPSPSVPSPA GPGSIGPQSH PGQMIPSPAL IPSPSPQVSS
NIPAPRNIGQ SPGQSLNTPG QAAAPSPLNP QEEHLYKEKY RSLQKYIEPL KRMIAKMEHD
DVDKMGKMKR LLDILCNPTC RIPLETLYKC EAALTSQLGT IREPPLNNPL VEAVSANLQS
PLGNHTLQRT FRPCLEALFG PDIKNLPTPA KQPRLAIDEP STSGSTGSQE IPHILQGEIA
RLDQKFKVSL DPCAIGDTKT IKLICWLDDK HLPCVPPVAV TIPEEYPFTS PSCSLIEQEY
NATPFLIQVQ KSFLARICKL PEMFSLSHLL DTWEMSVRQA CSPNPSLVAP SATSVLLGM
