MED15_ANOGA
ID MED15_ANOGA Reviewed; 762 AA.
AC Q5TP13;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 3.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 15;
DE AltName: Full=Mediator complex subunit 15;
GN Name=MED15; ORFNames=AGAP009886;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
CC {ECO:0000305}.
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DR EMBL; AAAB01008980; EAL39227.3; -; Genomic_DNA.
DR RefSeq; XP_553774.3; XM_553774.3.
DR AlphaFoldDB; Q5TP13; -.
DR SMR; Q5TP13; -.
DR STRING; 7165.AGAP009886-PA; -.
DR PaxDb; Q5TP13; -.
DR GeneID; 3292089; -.
DR KEGG; aga:AgaP_AGAP009886; -.
DR CTD; 3292089; -.
DR VEuPathDB; VectorBase:AGAP009886; -.
DR eggNOG; KOG4274; Eukaryota.
DR HOGENOM; CLU_011336_0_0_1; -.
DR InParanoid; Q5TP13; -.
DR OMA; CCLDDKR; -.
DR OrthoDB; 1424577at2759; -.
DR PhylomeDB; Q5TP13; -.
DR Proteomes; UP000007062; Chromosome 3R.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.246.20; -; 1.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR019087; Med15.
DR Pfam; PF09606; Med15; 2.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..762
FT /note="Mediator of RNA polymerase II transcription subunit
FT 15"
FT /id="PRO_0000304667"
FT REGION 70..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..455
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 78119 MW; A5D0ED241D520DBD CRC64;
MAEDNSWKTS NFRQSVVNKI NEAIQQTGMT SSKNGIEMEN HVFHKARNKD EYLGFVARLI
LHVREMTAAA QQAQQDGGGN SSQQGGGGGG GGSGMPDPIN ALQNLASQGT RPQMMGQMGV
GPGGPMGGQM GGAGQASNLL HSLRPQMQMG GMGGPMQGNR VGMGPGNQMG GMMGGPNQMQ
GPGAGMVGGM PGQMGVGMGP GGMSGGKIQM GVGPGGPNQM NPMVMGQIQA QLQNQNAMGG
QQMGTVGGTM NAGNQMGQMV GANAGMNPQA MGMASNQVVR QQQLQQQGMG QVQMGLGPGQ
MGQLSAGVQG GVGHGGPAMQ QQQQAGGMGP GAGPNQMNPG VAMGPGGVVG PAGGGGVMGP
GPNQMLGAGG AGGPGAGQQG NFVGMGANAM VRKPPEMMPG GNVYPGSGGA VRSVTPNNFL
RQSPSPSVPS PVGPGAHGPP SHPGQMIPSP ALIPSPNPHM GGVAQRSTIG QSPGGSLNTP
GQPGGAVPSP LNPQDEQLYR EKYRALTKYI EPLKRMIAKM ENDDIDKIAK MKRLLEILSN
PSVRIPLETL HKCEAALTSQ LGSIRETPTN NPLVEAVSSS LQAATGNHTL QRTFRPCLEA
LFGPDIKNLP PPAKQSRLAL DDTGAAVGTG GGEIPHILQG EIARLDQKFK VSLDQCAISG
TRTIKLICWL DDKNLPCVPP VAVTIPEDYP STAPSCSLIE QEYNATPFLI LVQKSLMARI
CKLPGLFTLS HLLDTWEMSV RQACSPNPTI VAPTGTSVLL GM
