MED15_ASHGO
ID MED15_ASHGO Reviewed; 1320 AA.
AC Q75BI6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 15;
DE AltName: Full=Mediator complex subunit 15;
DE AltName: Full=Transcription regulatory protein GAL11;
GN Name=GAL11; Synonyms=MED15; OrderedLocusNames=ACR285C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 1003; 1247 AND C-TERMINUS.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated gene transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
CC {ECO:0000305}.
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DR EMBL; AE016816; AAS51511.2; -; Genomic_DNA.
DR RefSeq; NP_983687.2; NM_209040.2.
DR AlphaFoldDB; Q75BI6; -.
DR SMR; Q75BI6; -.
DR STRING; 33169.AAS51511; -.
DR PRIDE; Q75BI6; -.
DR EnsemblFungi; AAS51511; AAS51511; AGOS_ACR285C.
DR GeneID; 4619822; -.
DR KEGG; ago:AGOS_ACR285C; -.
DR eggNOG; ENOG502QVXD; Eukaryota.
DR HOGENOM; CLU_009962_0_0_1; -.
DR InParanoid; Q75BI6; -.
DR OMA; KYWESMK; -.
DR Proteomes; UP000000591; Chromosome III.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd12191; gal11_coact; 1.
DR Gene3D; 1.10.246.20; -; 1.
DR InterPro; IPR033789; Gal11_coact.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR008626; Mediator_Med15_fun.
DR Pfam; PF05397; Med15_fungi; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1320
FT /note="Mediator of RNA polymerase II transcription subunit
FT 15"
FT /id="PRO_0000304670"
FT REGION 235..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..637
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1320 AA; 149419 MW; 245D5FEF1BC80AF0 CRC64;
MELDWRSTLS NQERSKYITE LAQILADISQ INGGARANFD LEKLKKTAEQ FETSLYASSS
SKELYLDAMR KRIAAMDAAK KKTLANQKQK AAAQRKGFGL APTLNPQMFL NQQAQARQQA
RPMRGSVGGG QSPVMMMPQH GVPAHVAHGV PPGVAVSQAK RAQLSLQQQQ QINEMKVAEI
PRELLQRIPN IPPGVTTWQQ VTELAQQKRL TQSDLQIAKQ VYQMHQQMMV KSKMQQASLN
QLTPQQRAQL QQRQQSTQQS QSAPPQAPQV AQSQQVPAQK PQQQQQQQQQ QQQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQHAAAQ
AQLQHPNAYQ QKNMMAQQSA AALQQGQQQP RQMGPQQARE VPNVLNKLNQ VFSPAEQKAL
YENGKKLVQD LQLAGKLPAS LTQQQQILYI KKYINQMVLK KLQQNIRLAQ QIGAANSANT
QSQMAAQAGA RFTPGMAQHS QFAQQQHTGN QAQVQSQVSQ SISQQQAQLT QKVQQAQQSQ
LQQTQEQDPQ HTQLADSFSQ RQFTSPTLAK PSANVSTIAQ QQTQPTALSQ SHPQQQQGSQ
AQQQLLQQQQ GSQAQQQLLQ QQQQQPPPPP PQPQQQTQQP QQPQQQQQPQ PQPQLQQQQQ
LGLQPHQPQL AQAQAQQPQP QQQTQQQTQQ QQQQQQQQQQ QQTQQQTQHQ PQPQLKPQSQ
QPQPVPQQVQ SQQPQQVQSQ QQPQPQQLSQ PAQQQSQQQQ QQQQQSQQQK LRQVQLPQQT
PKITLPRPTE QDMMILKRIN SEVAKSPLRL SNITNQLTPE QKQMIKNKLQ ANQQLLSNVD
NFIPTLYLIT RNEENVRQLL QIRMLAKEIM EHASKGVFIV PPDVVDKVIF RYQKYYEFIK
EQLLRRHQQL FSTRQQQMQQ QVVQQQQAGQ IKLGQNAVGA PQNPQVTTNT DIAMQQQRVQ
GSFQQMQQQI RQQQVKQAQL QQAQQQAQQQ QQAQQLQQGH MPVQQSMPLA GVQTVMATQA
ATLPQHASPV SSNTANIPKT GDAPVSIDSV TPVPPGIVNS SGPSPVAGKQ ILAATMVPQH
KLSPTKSDFA QAPTADNPYQ VDELRLKNLA IRKAEIMSRF KHRQEIFEHS PVDLFLCTLA
DCMGIKDGSY ELLAPIPALM VEQINGTGKK KFTKAQQRVR EQDSIECYVK DNKLMMSSKF
SADERSYSIH DRDISSCFLD LYGLSDCTSL SFDSSSAEPP TEQVNKKRSH DSLEISPAES
DSSLLNDSKK LKVDSPDDLF MTSNMMLDNK NAQPPIGLGL GVGLGEAGSS IWNWNYWESL
