ID   MED15_CAEBR             Reviewed;         785 AA.
AC   Q61L47; A8X7V1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 15;
DE   AltName: Full=Mediator complex subunit 15;
GN   Name=mdt-15; ORFNames=CBG09077;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). Required for
CC       activated transcription of the MtnA, MtnB and MtnD genes.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 15 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601284; CAP28712.1; -; Genomic_DNA.
DR   RefSeq; XP_002641213.1; XM_002641167.1.
DR   AlphaFoldDB; Q61L47; -.
DR   SMR; Q61L47; -.
DR   STRING; 6238.CBG09077; -.
DR   GeneID; 8583206; -.
DR   KEGG; cbr:CBG_09077; -.
DR   CTD; 8583206; -.
DR   WormBase; CBG09077; CBP42767; WBGene00030741; Cbr-mdt-15.
DR   eggNOG; KOG4274; Eukaryota.
DR   HOGENOM; CLU_021554_0_0_1; -.
DR   InParanoid; Q61L47; -.
DR   OMA; CVSKDEY; -.
DR   OrthoDB; 727190at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.246.20; -; 1.
DR   InterPro; IPR036529; KIX_dom_sf.
DR   InterPro; IPR019087; Med15.
DR   Pfam; PF09606; Med15; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..785
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   15"
FT                   /id="PRO_0000304669"
FT   REGION          101..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        273..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  83452 MW;  D789DD8BC08A19BB CRC64;
     MSEEDWPSPK FREHVIQRLE PELARNRQNA PNLPVPGDAR QVEEYVFAKC MSKDEYMRTI
     AKVINAINCN SKSAAVPSVL QPSQFHSPPC TTAVLGTGVG TPGYRAPVPP DPQPTSAQAR
     NPPVTTATTQ ASTTPSAPAV TGTVSASAAV AAAVASFPSP DSAALRAAPG GQTTPGSQPS
     SGAPGSTTPN APFPNGAGAQ PGAPTMNGGA GGPPMGQPPP QMGAPNMGMN GPGGYGGYGM
     MNGPPGAGGP MGGNPYGQPM KKEMDQSRGP WDPQGHMYQQ QQPWGGMPPQ QGHGGYPNRP
     MNGQQTTPTG TSSVLESLIN QPQQYPGHHN QMAPPGGDRN AAGGRAGVPG NPGGVPGAPQ
     RPGAMPVNQG VMSIEDQNVY QMKLRNMRGS CDSLRTRARQ CRQEGNHEAA HKLEVMLSVL
     EGRRVVSLEY LNHLETWIAR KQDFLNINPM GGGNPGHMGM NDPVMNGDHG MMSNGQVHNP
     YGHPGYNHGQ YGMGGPPPPH HMQMHQQQMW QQPQQQRMMP TDPMMMGGGG PMHGGPMYRG
     DMGHEMNSPV NSHRHNPYPS PAAMRNNMRG MQNGPGPIGR DRNSMSGSMS GPSSGAPSLN
     TMGTPKMGAP GSIGGLSNLD DFTYDDFLPN PIDALQPTLH IGPGSSMGGG PRVNLNDAAR
     KELQAMEGRF EIEPNHQRHD ANHIIVSAKM RNQPVPPLRL VVPITYPSGN VTVDRTAIDL
     DAYLYDDLQN VVHERLSRPG LSSLTDYLNA WEEQVNQYMQ QNQTNGGMDA AFGVGNDFFY
     DNLNL