ID   MED16_ASPCL             Reviewed;         957 AA.
AC   A1CQ63;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 16;
DE   AltName: Full=Mediator complex subunit 16;
GN   Name=sin4; Synonyms=med16; ORFNames=ACLA_025000;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 16 family.
CC       {ECO:0000305}.
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DR   EMBL; DS027059; EAW07784.1; -; Genomic_DNA.
DR   RefSeq; XP_001269210.1; XM_001269209.1.
DR   AlphaFoldDB; A1CQ63; -.
DR   STRING; 344612.A1CQ63; -.
DR   PRIDE; A1CQ63; -.
DR   EnsemblFungi; EAW07784; EAW07784; ACLA_025000.
DR   GeneID; 4701712; -.
DR   KEGG; act:ACLA_025000; -.
DR   VEuPathDB; FungiDB:ACLA_025000; -.
DR   eggNOG; ENOG502QQU3; Eukaryota.
DR   HOGENOM; CLU_007624_0_0_1; -.
DR   OMA; FFDTTWL; -.
DR   OrthoDB; 209987at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021665; Mediator_Med16.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13224; PTHR13224; 1.
DR   Pfam; PF11635; Med16; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..957
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   16"
FT                   /id="PRO_0000307624"
FT   REGION          855..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        862..881
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  105204 MW;  218162789E970D0B CRC64;
     MPLIMEDGIN VDDLFGEPGS LELGLSPPSN APIKGLPQRL DEMRLVGCCQ KIAWSRLGCV
     AYITPDGMRV NVRHLQCRPS DGKWVLSEDT PLLPVTEAHG GHPLVHLCWN ETGAELAVAD
     SSGRVSIYSI SIALNSIAGH RQATSDPDDD GAQIVGMMWL NVNRVVHAFH QAAKVQGRWA
     YSPFRRRPIG PFHPVNKAGL VCVTRSGTIR LLYQNPDSRW AEISTELKNT GYSDRLLTHA
     ALVSTQGGVL VATHSACQKL CLYRVQIAWN PTQYDPGQQK PPAPWPVPSF RFLHCKVESL
     CDVIGTNRNP GDNQGLPSFT NSVYGLTRLD IILPALDNPA GSTSTPWIVA VYSSPLHATP
     DHPQQQSPAS VIVRWQLDTG AVTLHPKFDE VGSKKSSAQM KPKLELRRLE DIYSDRYAIS
     IDQIEYGNVL AITYEDGSIV FHDPKTMAVF NGVDDTNTVT SLAQAGFHYP PEASGLHMAF
     SPNACAAVML DAEGQTQLRL TEHTYGAEGG LHDENKYSAA IAALTLAFCR GCGSDVNIDD
     VILILVRQLS SEAQINFINE VYRALSVNCN FTMEQDKLMN HIYIPRCLSL QAALGFKDKY
     TPRSSPSAIP WAILQLRHAS VLYAFFFQYN KGAPTESHDP DVLRMVLGNT KWALEFSFYV
     SNELFDLADE FESMASDQEA FTQKLKSTTS LPLIILLSSM SRAFLRFICR GLRGIHAGYA
     TAAPLTGDAR VYYAEIYQTL ENSPVRIDAY EKFLAGVDSA VRHAYHSAGF GDAERPGPEK
     ELLVNARVPP VLVSAVATIL RQTVPALKSE IDRITIYMGN YSWLGLAHDR RTEMYRRTRD
     VDIIKKIPLR SLGPYTEVDA APSGKTNAQG PPQQPQPQQQ RRRRCVRCCE ISGDTHPPRS
     LLSFRMIAKL GLLRSCVCGG MWTLVEPEVS APAADPPVSQ ATGRTPALMA IGLAGSS