ID   MED16_ASPFU             Reviewed;         955 AA.
AC   A4D9J5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 16;
DE   AltName: Full=Mediator complex subunit 16;
GN   Name=sin4; Synonyms=med16; ORFNames=AFUA_1G10525;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 16 family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000004; EBA27405.1; -; Genomic_DNA.
DR   RefSeq; XP_001481721.1; XM_001481671.1.
DR   AlphaFoldDB; A4D9J5; -.
DR   STRING; 746128.CADAFUBP00000976; -.
DR   EnsemblFungi; EBA27405; EBA27405; AFUA_1G10525.
DR   GeneID; 5076933; -.
DR   KEGG; afm:AFUA_1G10525; -.
DR   VEuPathDB; FungiDB:Afu1g10525; -.
DR   eggNOG; ENOG502QQU3; Eukaryota.
DR   HOGENOM; CLU_007624_0_0_1; -.
DR   InParanoid; A4D9J5; -.
DR   OMA; FFDTTWL; -.
DR   OrthoDB; 209987at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR021665; Mediator_Med16.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13224; PTHR13224; 1.
DR   Pfam; PF11635; Med16; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..955
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   16"
FT                   /id="PRO_0000307625"
FT   REGION          855..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   955 AA;  104750 MW;  50EFD8F18E83EBA5 CRC64;
     MPLIMEDGIN VDDLFGEPGS LELGLSPSTT SPRGLAQRLD EMRLIGCCQK IAWSKLGCIA
     YISQDGLRVN VRHLQCRPSD GKWVLSEETP LLPVTDAHGG HTLVHLCWNE PGVELAVADS
     SGRVSIYSIS IALNSIAGHR QAAFDPDDDG AQIVGMMWLN TQRTVHSFYQ AAKVQGRWAY
     SPFRRRPIGP FHPVNKAGLV CVTRSGIIRL LYQNPDGRWA EISAELKNTG YSDRLLTHAA
     LVSTQGGILI ATHSACQKLC LYRVHIAWTP TQYDPGQQKP PVPWPVPSFR FLHCKVESQC
     DVRGTNRHAG DNAPGLPSFT NSLYCLTGLD IVLPALDNPA GSTANPWVVA IYSAPLHVTQ
     DHPQQQGPAS VFVRWQLDTG PLTLHPKFDD VPSKKNNAQV KPKLELRRLD DVYSDKYAIS
     IDQIEYGNVL AITYDDGSVV FYDPKTMAVV NGVDDANTVT SLAQAGFHHP PEPSGLHISF
     SPNACAAVML DGEGQTHLRL TEHSYGAEGG LHDENKYSAA IAALTLAFCR GCGSDVNTDD
     ILLILVRQLT PEAQATFINE AYRALPINCN FTVEQDKLMN HPYIPRCLSI QAALGFKNKY
     TPRSFASSIP WAVLQLRHAS VLYAFFFQYN KGGTTEPHDP DVLRMVLGNT KWALDFSFYV
     LNELFDLADD FESLSGDQEA FTQKLKSTSS LPLIILLSSM SRAFLRFICR GLRGIYAGYA
     TAAPLSGDAR VYYAEIYQTL ESAPIRIDAY EKFLAGVDSA VRHAYHGAGF GDAERPGPEK
     ELLVNARVPP VLVPAVSTIL RQTVPALKTE IDRITIYMGD YSWLGLSNDR RTEMYRRSRD
     VDIIKKIPCR PTASALPETN ANANANQNGK SSTQVQQRRR RCVRCCEVSS DTHPPRSLLS
     FRMIVKLGLL RACVCGGMWT LEPSVYSSAQ PSGAPVGQAT GRTPALVAAG LAGSS