ID   MED16_CANGA             Reviewed;         973 AA.
AC   Q6FP10;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 16;
DE   AltName: Full=Mediator complex subunit 16;
GN   Name=SIN4; Synonyms=MED16; OrderedLocusNames=CAGL0J07524g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 16 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380956; CAG60985.1; -; Genomic_DNA.
DR   RefSeq; XP_448034.1; XM_448034.1.
DR   AlphaFoldDB; Q6FP10; -.
DR   STRING; 5478.XP_448034.1; -.
DR   PRIDE; Q6FP10; -.
DR   EnsemblFungi; CAG60985; CAG60985; CAGL0J07524g.
DR   GeneID; 2889597; -.
DR   KEGG; cgr:CAGL0J07524g; -.
DR   CGD; CAL0132966; CAGL0J07524g.
DR   VEuPathDB; FungiDB:CAGL0J07524g; -.
DR   eggNOG; ENOG502QWAC; Eukaryota.
DR   HOGENOM; CLU_311703_0_0_1; -.
DR   InParanoid; Q6FP10; -.
DR   OMA; WYQFSNS; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0070202; P:regulation of establishment of protein localization to chromosome; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR021665; Mediator_Med16.
DR   PANTHER; PTHR13224; PTHR13224; 1.
DR   Pfam; PF11635; Med16; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..973
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   16"
FT                   /id="PRO_0000307627"
SQ   SEQUENCE   973 AA;  110550 MW;  A0A4EBBB3739075B CRC64;
     MCELNNKRVS WSKTGLIAYA DEQSTYGNLC ISFLETINGV NCRFHPPQRY VIHPQLHEVP
     LKTETGNGIN GASGSSTAQS NIHGTTSVPG SAGKHQHQFF YDISSIHWNN WFSLPGDMLA
     VCDELGNMTM LIAGQSPDGP TTLDKLTMLF QDNVYKIHNH VMQLEPEREN TDSKLERKKT
     KKEYNTTILD FHWLSSSKPV IVSQFCAFDS SINMYRNKAQ QLSPHGIFHP PFMKYAGLAI
     RRNGQLDFWY QFSNSKDHKK ITLQLFNPHN ERSKGLDFLQ YAKITSVNND NSILITTYSR
     LTGKLSFYKL FVDWNVNTAK PVVLNDPSLK IKHILDATVD QTDDEGRILD FTHVHVLAKV
     VAEKDAAPEV LLAYDVVGTP ESLIKRFKLG QVRLPLDYLG ILKPELNTSN ENHNQALRSN
     RSNLRFLGVL NLHHKVASIS SEVLDGFVSF YYRNGEIEIY NQNDWKLETE RLLNQGPQGK
     FSNIITSILS AGFKYPTIKN LGTVEWIRVS PAMAGILYKY RHDDLPQFQP MNIDDVSDKS
     KDEINAATMA FGYVTSAHRQ LSGEDIALAC KQHILKIAKI DEKRAKDFTT TLMFNLYNFF
     NFSPGAPKEL MDKIISSRPL QKVMLLQLEL GSIFTDENTC EMARVILYLK NVSFAFNGVA
     RNLQFAIEQM TNSTNSSNPP LSGDKFFQTA FSKQDLVHSL IPVTKWFVKF ITYLIQQILI
     LTNDPENPDN RLVLGVFGAK IPRTLILTIL KEIKNVTAII TKFPETNYPI LNESSTYLKM
     LLIESPINFE KFETFLMDVN NKLSAFSEQQ PSIMREPTLL VRSSVPNELN KITEFLLQYS
     SNTVISHADA SAIYFSDTSG LRISCDEFFE PGVHRLLQPI EDGIVIDEKN MPATFRDSKT
     FTKLTYDGIT YDRFSKEELS DNKLKRCNRC GAVTKAGYPI PTNKTIVPTS ISTRRWPTMY
     TRMCICLGML YEL