ID   MED16_NEOFI             Reviewed;         955 AA.
AC   A1D327;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 16;
DE   AltName: Full=Mediator complex subunit 16;
GN   Name=sin4; Synonyms=med16; ORFNames=NFIA_015120;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 16 family.
CC       {ECO:0000305}.
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DR   EMBL; DS027688; EAW22820.1; -; Genomic_DNA.
DR   RefSeq; XP_001264717.1; XM_001264716.1.
DR   AlphaFoldDB; A1D327; -.
DR   STRING; 331117.A1D327; -.
DR   EnsemblFungi; EAW22820; EAW22820; NFIA_015120.
DR   GeneID; 4590885; -.
DR   KEGG; nfi:NFIA_015120; -.
DR   VEuPathDB; FungiDB:NFIA_015120; -.
DR   eggNOG; ENOG502QQU3; Eukaryota.
DR   HOGENOM; CLU_007624_0_0_1; -.
DR   OMA; FFDTTWL; -.
DR   OrthoDB; 209987at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021665; Mediator_Med16.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13224; PTHR13224; 1.
DR   Pfam; PF11635; Med16; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..955
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   16"
FT                   /id="PRO_0000307630"
SQ   SEQUENCE   955 AA;  104664 MW;  E204DA676B5C94BC CRC64;
     MPLIMEDGIN VDDLFGEPGS LELGLSPSTP SPRGLAQRLD EMRLIGCCQK IAWSKLGCIA
     YISQDGLRVN VRHLQCRPSD GKWVLSEETP LLPVTDAHGG HTLVHLCWNE PGAELAVADS
     SGRVSIYSIS IALNSIAGHR QAAFDPDDDG AQIVGMMWLN TQRTVHSFYQ AAKVQGRWAY
     SPFRRRPIGP FHPVNKAGLV CVTRSGIIRL LYQNPDSRWA EISAELKNTG YSDRLLTHAA
     LVSTQGGILV ATHSACQKIC LYRVHIAWTP TQYDPGQQKP PAPWPVPSFR FLHCKVESQC
     DVPGTNRNAG DNAQGLPSFT NSFYCLTGLD IVLPALDNPA GSTANPWVVA IYSAPLHVTQ
     DHPQQQGPAS VIVRWQLDTG PLTLHPKFDD VPSKKNNAQV KPKLELRRLD DVYSDKYAIS
     IDQIEYGNVL AITYDDGSVV FYDPKTMAVF NGVDDANTVT SLAQAGFHHP PEPSGLHISF
     SPNACAAVML DGEGQTHLRL TEHSYGAEGG LHDENKYSAA IAALTLAFCR GCGSDVNTDD
     ILLILVRQLT PEAQATFINE AYRALPINCN FTVEQDKLMN HPYIPRCLSI QAALGFKNKY
     TPRSFASSIP WAVLQLRHAS VLYAFFFQYN KGGATEPHDP DVLRMVLGNT KWALDFSFYV
     LNELFDLADD FESLSGDQEA FTQKLKSTSS LPLIILLSSM SRAFLRFICR GLRGIYAGYA
     TAAPLSGDAR VYYAEIYQTL ESAPIRIDAY EKFLAGVDSA VRHAYHGAGF GDAERPGPEK
     ELLVNARVPP VLVPAVSTIL RQTVPALKTE IDRITIYMGD YSWLGLSNDR RTEMYRRNRD
     VDIIKKIPCR PAASALPETN ANANANQNGK SSTQVQQRRR RCVRCCEVSS DTHPPRSLLS
     FRMIAKLGLL RACVCGGMWT LEPSVYSSAQ SSGAPVGQAT GRTPALMAAG LAGSS