ID   MED16_XENTR             Reviewed;         828 AA.
AC   Q08D69;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 16;
DE   AltName: Full=Mediator complex subunit 16;
GN   Name=med16;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 16 family.
CC       {ECO:0000305}.
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DR   EMBL; BC123916; AAI23917.1; -; mRNA.
DR   RefSeq; NP_001072641.1; NM_001079173.1.
DR   AlphaFoldDB; Q08D69; -.
DR   SMR; Q08D69; -.
DR   STRING; 8364.ENSXETP00000038276; -.
DR   PaxDb; Q08D69; -.
DR   DNASU; 780097; -.
DR   GeneID; 780097; -.
DR   KEGG; xtr:780097; -.
DR   CTD; 10025; -.
DR   Xenbase; XB-GENE-967800; med16.
DR   eggNOG; ENOG502QQ3H; Eukaryota.
DR   HOGENOM; CLU_018773_0_0_1; -.
DR   InParanoid; Q08D69; -.
DR   OrthoDB; 493637at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR021665; Mediator_Med16.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13224; PTHR13224; 1.
DR   Pfam; PF11635; Med16; 1.
DR   SMART; SM00320; WD40; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..828
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   16"
FT                   /id="PRO_0000307620"
FT   REPEAT          68..107
FT                   /note="WD 1"
FT   REPEAT          199..241
FT                   /note="WD 2"
FT   REPEAT          264..308
FT                   /note="WD 3"
FT   REPEAT          622..663
FT                   /note="WD 4"
FT   REPEAT          777..816
FT                   /note="WD 5"
SQ   SEQUENCE   828 AA;  92540 MW;  3E3CFB2FFF04EA71 CRC64;
     MDVGYVCEWD KRPRTSHCPS IPLVCAWSCR NLIAFTTDQR NEEEKDITNL IHILDTEHPW
     DVYSINSGHQ EVITSLEWDQ SGSRLLSADA DGRIKCWGMT DHLANSWQSL VGSEVDGDPI
     VALSWLHNGV KLALHVEKSG VSSFGEKFSR VKFSPSLTLF GGKPMEGWIA VTVSGLVTVS
     LLKPNGQVLT ATESLCRLRC RVALADIAFT GGGNIVVATC DGSSTSPVQF YKVCVSVVSE
     KCKIDTEILP SLFMRCTTDP ARKDKFPAVT HLKFLARDMS EQVLLCASNQ CSSIAECWSL
     RKEGLPLNNI FQQLSPAVSD KQPMILKWRI LSATNELERV SAVALPKLPI SLTNTDIKVA
     SETKFYPGLG LALAFHDGNV QIVHRLSLQP MAVLYGSSLR PSEEPSLKRQ RSPTPCIHFK
     ALQMSWTSLA LVGLDTQGKL SMLRVSPSMG HSLDMSTSLR HLLFLLEYCM VTGYDWWDIL
     LHVQPGMVHN LVEKLNEEYT RQNAALQQVL STRILAMKAS LCKLSQTTVT RVCDYHAKLF
     LISISCTLKS LLRPHVLNTP DKSPGDRLTE ICNKFTDTDI DKVMINLKTE EFVLDMPTLQ
     SLQQLIQWLG DFVLYLLASL PNQGSSVRPG HSFLRDGASL GTLREMMVMI RIWGLLKPSC
     LPVYTATSDT QDSMSLLFRL LTRLWLCCRD ESHPCDPDES LIDECCLLPS QLLIPNMDWL
     PLGNGIISRL QSKLPLRLQF GKPPVAPSYA SVQYEAYTRS PTQPKIDHLR RLHLGTFPTE
     PCKSCTRCGC VTMLKSPNKA TAVKQWEQRW IKTCLCGGLW RKMPHTYS