ID   MED16_YARLI             Reviewed;         924 AA.
AC   Q6C1B1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 16;
DE   AltName: Full=Mediator complex subunit 16;
GN   Name=SIN4; Synonyms=MED16; OrderedLocusNames=YALI0F17776g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 16 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382132; CAG78360.1; -; Genomic_DNA.
DR   RefSeq; XP_505551.1; XM_505551.1.
DR   AlphaFoldDB; Q6C1B1; -.
DR   STRING; 4952.CAG78360; -.
DR   EnsemblFungi; CAG78360; CAG78360; YALI0_F17776g.
DR   GeneID; 2908644; -.
DR   KEGG; yli:YALI0F17776g; -.
DR   VEuPathDB; FungiDB:YALI0_F17776g; -.
DR   HOGENOM; CLU_013428_0_0_1; -.
DR   InParanoid; Q6C1B1; -.
DR   OMA; FFDTTWL; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR021665; Mediator_Med16.
DR   PANTHER; PTHR13224; PTHR13224; 1.
DR   Pfam; PF11635; Med16; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..924
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   16"
FT                   /id="PRO_0000307632"
SQ   SEQUENCE   924 AA;  103213 MW;  5ED5DF283CE64190 CRC64;
     MYQYAPSHNL DHIEWNHAHL IYPPNLAIPT SPVNPPATQL NQPVQMTIDF DSIIEPKLGA
     RESISWNRNG IIASIGDEGV ETNLLVCTDG QDWVLTKPTL YAPKSILQPP TTSFVTPHRA
     FCHVEWSPSG SDLAIIDTLG SLYIYSQYTT LSPITCLRKP PSEELTTPID LNAIVGFTWV
     APEKPVILTN PGLKAGGNEK SKQKLSDVKD FPTGQTSQLL GYSGISVTYG VSQGLHLGPR
     IPQGFGACIG VTRSQVLKLW TQNGPSQPYN LVKLSLNQLH SDDIISHASF AGTKDHKMLL
     ACYSPAGAIY LYRIEVEWSK EEEPKLRATR LLKETLMPQS GAPARLTDLK LFSIRSNQVS
     SETEAEMVCV FTDTKGATTN RYELQSHTPD LNSTFYSLGT NDSSASSTTT HKTHIISLVE
     TTTSNKIVNI GSQVYDSIFF AAHEDGILNF RYRGNVSSST KGTPFNMFSD AGYAFTPLPK
     GSDRPDYICV SPTCASYVYK TKDGLKLRII DNKIPDADLT VAQMVDSAFV LSLRHSVSCI
     SAVCNDDVMM VMRREIQRVS KLAPALETQF PLLLLAESHK AINFSLDLKK DHQMDKIMIN
     PSLQRLLTMQ TVIGTQHGWT RNVTSRLSWC FLNLRLVSFS LTFTLRAIGQ QKPGVAPNHA
     MRIHYLMSLS GLKRWCLDFA AYLCQELLAA SNEGPSYFQK QHVALPMVMA RSSRMLLMYS
     WRGIRSLDTI LMQKPGTETQ EAGLASQRQR ELSHFTPISM TFFEQLFNVI DSHTKQVAEN
     VEDRLGLEQQ LLFQGMIPQQ FLPLAKRCVD EFDKFRKTND LSPLYFYNVS WLGLDEHYDG
     RPAPTPAMAP YRNVTSTGLK IDCLRKFIIE RQEGSILRVC QRCAGTSVFV DSSDGKQFTG
     THWTFAFQRN CWCGGMWIPE SLGV