ID   MED17_AEDAE             Reviewed;         645 AA.
AC   Q17JT4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=MED17; ORFNames=AAEL001883;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477230; EAT46978.1; -; Genomic_DNA.
DR   RefSeq; XP_001654224.1; XM_001654174.1.
DR   AlphaFoldDB; Q17JT4; -.
DR   SMR; Q17JT4; -.
DR   STRING; 7159.AAEL001883-PA; -.
DR   GeneID; 5572828; -.
DR   KEGG; aag:5572828; -.
DR   VEuPathDB; VectorBase:AAEL001883; -.
DR   eggNOG; KOG4512; Eukaryota.
DR   HOGENOM; CLU_028003_1_0_1; -.
DR   InParanoid; Q17JT4; -.
DR   OMA; CQIYQHQ; -.
DR   OrthoDB; 976669at2759; -.
DR   PhylomeDB; Q17JT4; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..645
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304704"
SQ   SEQUENCE   645 AA;  72113 MW;  6C2EFE03621BB274 CRC64;
     MSVSANISVE APIESQIQEI AYDGTEIYQL PPTLSEHLAK CAAKIDFSKT VNDLDLVKQS
     IKKEDEKKDD DSKDAAAHFQ SSLWPWDSVR NKLKDAFTEV CVLSDVLAIA KEKRFMVLDP
     IPQEPPEVKQ MVQVYARKKA LASAANILLT GAERLKTAHT DQGGNRSAPD FHIELLRLRR
     NWRLKKVSNT IIGDLSYRTA GSKFMHPGMF EVTKAEDEDN NDENASAAAG TIATTGTAPE
     PKLTSLKVNV PTELQGVAFI KVITQKDQGD LCTATLNMMG STQLFPQAGE WQKTLDFAQN
     VLFCKELFNQ LAREAVQLQA PIPHVVVGNQ IRATLLPGIQ LVISLCHSTS SDSNNSSEPI
     KDHDHVLEHS LHQLLREFHH KNTHHPFPHP ASAPLGPSKK RMLAGPSAFD RYELLEMTKS
     QTLLEQIIAQ AQHIFTRRRA QYVLDTLARE VKDPQITSHW NAMNSPTMSC VKINITSHGY
     DANLRTSLVI HVKERSLKCI CRDGRIMHMS YEMQELRDLI LYQISQHQIV CLQSLAKCMA
     WQILSNSSHL GIGSVEPLGN ASSCVLASPN SDRLIAVQVR CDPQLDVKVY IAQSPGKDFF
     PGSLVQGRHW EHLGGHFKEL RFDKMEGKNF HNKMEFLMAS LTSQT