ID   MED17_ANOGA             Reviewed;         645 AA.
AC   Q7PVZ2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=MED17; ORFNames=AGAP009141;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AAAB01008984; EAA14731.2; -; Genomic_DNA.
DR   RefSeq; XP_319901.2; XM_319901.3.
DR   AlphaFoldDB; Q7PVZ2; -.
DR   SMR; Q7PVZ2; -.
DR   STRING; 7165.AGAP009141-PA; -.
DR   PaxDb; Q7PVZ2; -.
DR   GeneID; 1280098; -.
DR   KEGG; aga:AgaP_AGAP009141; -.
DR   CTD; 1280098; -.
DR   VEuPathDB; VectorBase:AGAP009141; -.
DR   eggNOG; KOG4512; Eukaryota.
DR   HOGENOM; CLU_028003_1_0_1; -.
DR   InParanoid; Q7PVZ2; -.
DR   OMA; CQIYQHQ; -.
DR   OrthoDB; 976669at2759; -.
DR   PhylomeDB; Q7PVZ2; -.
DR   Proteomes; UP000007062; Chromosome 3R.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..645
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304705"
FT   REGION          215..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   645 AA;  72064 MW;  04E400D2AA5E4EE3 CRC64;
     MSLSANISVE APIENQIQEI AYDGTEIYQL PPTLSEHLAK CATKIDFSKT SSDIDLLQQS
     IKKEDEKKEE ESKDPKEQFQ SSLWPWDSVR NKLKEALTEV CVLSDVLNIA KEKRYMVLDP
     IPQEPPEVKQ MVLVYARKKA LASAANILQS GVERLKAVQS DQGVSRSNST DFHIELLRLR
     RNWRLKKVSN TIIGDLSYRT AGSKFMHPGM FEVTKAEDEE SGSPPASPSG SGAAGTVACP
     KINSALRVNV PTELQGVAFI KVITQKDQED LCTATVNMMG STQLVPQAGA WQQTLEYAQN
     VLFCKELFNQ LAREAVQLQA PIPHVVVGNQ IRATLLPGIQ LIISLCHSTS SDSNNSSEPI
     KDHDHVLEHS LHQLLREFHH KNTHHPFPHP ASGPLGPSKK RMLAGPSAYD RHELLEMTKS
     QTLLEQIIAQ AQHIFTRRRT QYVLDTVARD VKDPMITSHW NAMNSPTMSC VKINITSHGY
     DANLRTSLVI HVKERSLKCI CRDGRIMHMS YEPQELRDLI LCQISQHQIV CLQNLAKCMA
     WQILSSSSHL GIGSVEPLGN ASSCVLASPN SDRLIAVQVR CDSQIDVKVF IAQSPAKDFF
     PGSLVQGRHW EHLGGHFKEV RFDKMEGKNF HNKMEFLMAS LTSQS