ID   MED17_ARATH             Reviewed;         653 AA.
AC   F4K460;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
GN   Name=MED17; Synonyms=MED17_1; OrderedLocusNames=At5g20170;
GN   ORFNames=F5O24.60;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, AND NOMENCLATURE.
RX   PubMed=17560376; DOI=10.1016/j.molcel.2007.05.007;
RA   Baeckstroem S., Elfving N., Nilsson R., Wingsle G., Bjoerklund S.;
RT   "Purification of a plant mediator from Arabidopsis thaliana identifies PFT1
RT   as the Med25 subunit.";
RL   Mol. Cell 26:717-729(2007).
RN   [4]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=22021418; DOI=10.1104/pp.111.188300;
RA   Mathur S., Vyas S., Kapoor S., Tyagi A.K.;
RT   "The Mediator complex in plants: structure, phylogeny, and expression
RT   profiling of representative genes in a dicot (Arabidopsis) and a monocot
RT   (rice) during reproduction and abiotic stress.";
RL   Plant Physiol. 157:1609-1627(2011).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. The Mediator complex, having a compact
CC       conformation in its free form, is recruited to promoters by direct
CC       interactions with regulatory proteins and serves for the assembly of a
CC       functional preinitiation complex with RNA polymerase II and the general
CC       transcription factors.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000269|PubMed:17560376}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AF296825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92808.1; -; Genomic_DNA.
DR   RefSeq; NP_197517.3; NM_122024.4.
DR   AlphaFoldDB; F4K460; -.
DR   IntAct; F4K460; 7.
DR   STRING; 3702.AT5G20170.1; -.
DR   iPTMnet; F4K460; -.
DR   PaxDb; F4K460; -.
DR   PRIDE; F4K460; -.
DR   ProteomicsDB; 238288; -.
DR   EnsemblPlants; AT5G20170.1; AT5G20170.1; AT5G20170.
DR   GeneID; 832140; -.
DR   Gramene; AT5G20170.1; AT5G20170.1; AT5G20170.
DR   KEGG; ath:AT5G20170; -.
DR   Araport; AT5G20170; -.
DR   TAIR; locus:2149294; AT5G20170.
DR   eggNOG; ENOG502QT7Z; Eukaryota.
DR   HOGENOM; CLU_034793_0_0_1; -.
DR   InParanoid; F4K460; -.
DR   OMA; WWLVMDD; -.
DR   OrthoDB; 311604at2759; -.
DR   PhylomeDB; F4K460; -.
DR   PRO; PR:F4K460; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4K460; baseline and differential.
DR   Genevisible; F4K460; AT.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0035196; P:miRNA processing; IMP:TAIR.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..653
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000418141"
FT   REGION          246..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   653 AA;  73404 MW;  D06CDC043C9AA5AD CRC64;
     MDSDMEISLD RLPIKRLESI EENGAERFPS DVDYDDKRVS LIRRIDFAWA LEEEDELKKK
     KQKKSSKDSV EQWKWKGMVE NLQLAHQELT VIIDLIDTVQ ANDAVTVAGM TRPKPMPNEI
     LSDLAVSTAT KLQGYRNLGN YFKQSAKALE QKINREARFY GALIRLQRNW KVKRQRMLAS
     NASNEGFTID LSDSSLYDPT SGFRPSTLST IRVDHDSAGM LAINVPQDSW YSLRFGYVGL
     NPIGNSNESD EHIDSTTGHD IPGTSEKLSA SDDKYVKETH SLLREVHKSI FAEQLFDMLN
     REAFNEGVGF NISGLRENFM EMSIGQGASL FVSLHPSGKN PSIKKSESAT LLIESSGRVE
     PAEGGDYRLK KLGFPNRTSY EIYLQQIFHE HAFGKAKDQL KSKSIRASNQ TEKDSNSGLL
     DHFCLSLTHR IFSNRVLVHL ESVVCKVPYL HLISHPTWNS RTSSWTVFMT VPPSIIPQGR
     SETQSPDGKR NLKTQFRTKV VVKDDCISVE AECTPNVVGL LKSSSCNLFS INKYECDVAD
     LPVMILQQVA SQIVCWLLEE ARTVGTKASR EFLSLSLEIV EGERVSLVAH VNPEDAKGCI
     SWWLVMENGC TEEREGVSES RKLLGHLSLD VLYSVLMDLI NLCGTGRNAL ERL