ID   MED17_ASHGO             Reviewed;         639 AA.
AC   Q75D58;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; OrderedLocusNames=ABR165W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AE016815; AAS50937.1; -; Genomic_DNA.
DR   RefSeq; NP_983113.1; NM_208466.1.
DR   AlphaFoldDB; Q75D58; -.
DR   SMR; Q75D58; -.
DR   STRING; 33169.AAS50937; -.
DR   EnsemblFungi; AAS50937; AAS50937; AGOS_ABR165W.
DR   GeneID; 4619223; -.
DR   KEGG; ago:AGOS_ABR165W; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_023188_0_0_1; -.
DR   InParanoid; Q75D58; -.
DR   OMA; PKINDKR; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0001139; F:RNA polymerase II complex recruiting activity; IEA:EnsemblFungi.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..639
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304708"
FT   REGION          32..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          245..271
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        135..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  72164 MW;  276AE65C97D50691 CRC64;
     MEPDDGHNSL NQDNGIPIVL DPNLINLRSR AASATVTTNG TTADSSEDSG SQQSVSSAPI
     QQNSEEHSLV SNPYETYGRM PLQKLIPLIL QMRNASSFSE LTEEDLLRDI EREEKGILTT
     GLDVEGDIEM GDADEESDLK PQEITDDDSN ARLKPNNDSA IPQEEFNQMK REVLEHINLA
     LNESSLSLEF ISLLLSSVRP SVGVGSMSPF LKRSVPTASL NADKVELPPK NKTETLTLAV
     INRGWKLRSL EDSKALLKEN YAKLQKSLEV EHAHWAMISQ HISSTDVVFK MRDRQTGKRS
     LAVKYGYEDS GSLYKQDRGV AVLRHNMDLN KLELVPISNS KEEVHITANS VERFMRVHIY
     TKIEEEDDYI LSGESSIDDQ SLLQPCHDDI SRQIARLKFF IFERELMYQL KKEAVSLMPY
     GVNFENENKV VLESPGERIE FEMVPLDDSA LLSTHEPRRV NDKRANIILI LLRMLLVVIH
     KKQLRRGLKP ATSKHKYRAD GDLLLLRPVL GRIRHRNYLQ VVKRVVTECV LNIVPGSSIE
     LLPQRSEPDT LHAREANIAS LNKQIGLFDK ILRMPRSELR TSLGAKGVID LTLKSSNYCN
     AIIQVIYADS AGKTVFDTVF TELKELEEFL HFIVSEYVL