ID   MED17_ASPCL             Reviewed;         641 AA.
AC   A1CLT5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=srb4; Synonyms=med17; ORFNames=ACLA_078120;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; DS027057; EAW09064.1; -; Genomic_DNA.
DR   RefSeq; XP_001270490.1; XM_001270489.1.
DR   AlphaFoldDB; A1CLT5; -.
DR   STRING; 5057.CADACLAP00007200; -.
DR   PRIDE; A1CLT5; -.
DR   EnsemblFungi; EAW09064; EAW09064; ACLA_078120.
DR   GeneID; 4702668; -.
DR   KEGG; act:ACLA_078120; -.
DR   VEuPathDB; FungiDB:ACLA_078120; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..641
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304709"
FT   COILED          159..186
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   641 AA;  71618 MW;  F0CBA2A0424F40F3 CRC64;
     MSDQFTLPLR PLIEERDHQD LLPVEIAQIS AQWGSFRDVN EETLRAKIEE EKNKEYTIDD
     EEGEGASVDL DTTERLDQLY KKRAEITQFA MQAHMEAMFA LDFISLLLSK YTPRQAETSM
     SAFLKQVAPL GSLTAELVNP PPKSEAAVRD AKAVSRGWRL QSFNAAADKL LKSAARLETE
     VASETRYWSE VLAVKDKGWK VCRLPREGQA LGVQYGFLEA TPIFRDRGLA ALRRSEDGGL
     ILDKGLVPAK AKTVRVRVKN RGVVTGCSKP YRSAVQDSES IEGRILQARD TLYEEELFYE
     LVREARIMGS QGVSTGQNLV QFSVSEDEEV LLDLVDPDVA YADDSETSLE HTVVADALAH
     SIRILLSYAH RQNRRRRTQP PPPLTQKRRH VPEYLLLRPT MAYLQHSFHV RWLESFLGDV
     YGVLRAAGLE SKFTATPYAS VDLAHIDRSV PTVEGLVKQF LLPLESTFSA DLITPQTSFN
     VKTRTNLLVP PFGTHFEIAL NMPHYPDVQP PSRIGQHDQV AMMVTHFLLL DIVSTISHGQ
     GQPVKSETKT TPLSWEVTYP HHGELLAVAS DGRQKKMKVQ LSRSELSVQM FETHGTDSYS
     RLVGAEGGML PLPSQSQTWT ADAATPHPSL MEFVASVSKS A