ID   MED17_ASPFU             Reviewed;         639 AA.
AC   Q4W9B7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=srb4; Synonyms=med17; ORFNames=AFUA_4G00950;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000017; EAL84324.1; -; Genomic_DNA.
DR   RefSeq; XP_746362.1; XM_741269.1.
DR   AlphaFoldDB; Q4W9B7; -.
DR   STRING; 746128.CADAFUBP00009852; -.
DR   EnsemblFungi; EAL84324; EAL84324; AFUA_4G00950.
DR   GeneID; 3503712; -.
DR   KEGG; afm:AFUA_4G00950; -.
DR   VEuPathDB; FungiDB:Afu4g00950; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   InParanoid; Q4W9B7; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..639
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304710"
FT   COILED          160..187
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   639 AA;  72232 MW;  6CBA430C45C9357B CRC64;
     MADDRFTLPL RPLIEKRDRP DPLPLEIAQI NAQWGSFRDV SEESLRAKIE EEKSKEYTIE
     EEEGEGAGAE LDTTERLDQL YKRRAEIIQF AMQAHMEAMF ALDFVSMLLS KHTPRQAETS
     MSAYLKQVAP LGSLHSEIIN PPPKSEAVVR DTKTVSRGWR LQSFNAAADK LLKSASRLEN
     EVASETRYWH EVLAVKDKGW KLCRLPRQGQ TLGVQYGFLE ATPIFRDRGL AALRRSEDGT
     LILDKGLVPT KAKTVRVRVK DCGIITGCSK PYRSAAQDPD SIEGRILQAR DTLYEEELFH
     ELFREARIMG SQGVTTRQNL VQFPVSEEQE ILLDLVDPDQ EVYVDDEATK SEEHNVLADA
     LAHLIRILLC YAHRQNLRRR TQPPPALSPK RRHIPEYQLL RPIMAYLQHS FHVRWLETFM
     KDVYGVLQSA GLSCSFTATP YSSVNLSNID RSVPKVEGLI RQFLLPLEST FSADLLTPQS
     SFKVKSRTNL SVPPFGTQFE ILLNLPHYPD VHPPHRIGLH DQAANIITHF IMLDIVAAIE
     LQTSPALSIS KTEAKSVSWE ATYPHHGELL SVSIDGKQKK MKVILSRDEL TIQTYDVLGL
     ERYSRAAPET TPGLQTHTWK AGPTTAPSLM EYVAAVSQR