ID   MED17_ASPOR             Reviewed;         638 AA.
AC   Q2UJ16;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=srb4; Synonyms=med17; ORFNames=AO090003001391;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AP007155; BAE58449.1; -; Genomic_DNA.
DR   RefSeq; XP_001820451.1; XM_001820399.2.
DR   AlphaFoldDB; Q2UJ16; -.
DR   STRING; 510516.Q2UJ16; -.
DR   EnsemblFungi; BAE58449; BAE58449; AO090003001391.
DR   GeneID; 5992434; -.
DR   KEGG; aor:AO090003001391; -.
DR   VEuPathDB; FungiDB:AO090003001391; -.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   OMA; GVTTRQN; -.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..638
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304711"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  71749 MW;  112ADE9C6B1308E2 CRC64;
     MSDSFNLPLR PLTEKRERPD PLPVEIAQIN AQYGSFRDVT EDSLRAKIEA DKNKDPWFDK
     EENDNASADE DTTERLDQLY KRRAAITQFA LQAHMEAMFA LDFVSLLLSK HTPRQAEMSM
     SAYLKQVAPL GSLNSEIVNP PPKPESAARD TKNVSRGWRL QNFNSAASKL LDSATRLEAE
     VASETRYWDE VLAVKEKGWK VSRLPRERQA LGVQYGFLEA TPIFRDRGLA ALRRTNDGSL
     ILDKGLIPLK ARTVRVRVRS RGQITGCSKN QPASDNTESI ESRILQARDT VYEEELFHEL
     VREARILGSQ GVTTRQNLVQ FPVSEEQEVL LDLIDSDQIS PENDVVSSNE HAVVADALAH
     AIRILLAYAH RQNLRRRTQL PTPLTPKRRQ TPEYQLLRPV MAYLQHSSHV RWLESLLNDI
     NQILKSAGIT CDFTATPFSS LSLRRTISGL PKVEALVQEF LLPYESTFSA QLVTPQSSFR
     VKVRTNVTTP PLGTHYEISV NMPQYPDVRP PNRIGLQDEA ASILTHFVLL DILTAITHAK
     GSSVKGIKQE TGHLLTWQAA YPHNGELLAL SSTGQHKKMK VSLSRHELTV RVYSIRGIDG
     FGKPAVDKTP AMRSQTWKCD GTPDQPNLMD FIAEVSKE