ID   MED17_ASPTN             Reviewed;         634 AA.
AC   Q0CG59;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=srb4; Synonyms=med17; ORFNames=ATEG_07333;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; CH476603; EAU32717.1; -; Genomic_DNA.
DR   RefSeq; XP_001210019.1; XM_001210019.1.
DR   AlphaFoldDB; Q0CG59; -.
DR   STRING; 341663.Q0CG59; -.
DR   EnsemblFungi; EAU32717; EAU32717; ATEG_07333.
DR   GeneID; 4319166; -.
DR   VEuPathDB; FungiDB:ATEG_07333; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..634
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304712"
FT   REGION          51..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   634 AA;  71308 MW;  1AF87EEAEAAB9542 CRC64;
     MPDSLSLPLR PLIDKREHQD SLPVEIAQIN AQWGAFRDVS EDSLRAQIEA DKHKDPWAED
     EESDGQSAAD VDTSERLEQL YKRRAEITNF ALQAHMEAMF ALDFVSLLLS KYAPRQAETS
     MSAILKQVAP LGSLNAEVVN PPPKPESTAK DIKTVSRGWR LQNFDAAANR LLDAATRLES
     EVASETRYWE EVLAVKNKGW KVCRLPRERQ ALGVQYGFME ATPIFRDRGL AALRRADDGR
     LFLDKGLAPQ RTRMLRVRVK HCGGISGCSK VQPAVTEDVE SIENRILQAR DTLYEEELFH
     EVFREARMLG NQGVITRQNL VQIPVSEEQD ILLDLVDDQD LLSDETPMSH EHDTLANAIS
     HSIHILLAYA HRQNLRRRTQ PPPPLSTKRR HTPEYLLLRP VMAYLQHSSH VRWVESFLND
     IHRVLQSAGL QCEFKATPFS SIRLPTKHTI PTVEALVQTF LAPLESTFSC KLPSSHGSFR
     VRVRTNAVVP PFGTHFDISV DMPEYPDIQP PSRIGLQEEV ATALTHLTML DILTAIRQDQ
     KSAVEPSEDS KPTEQCLTWS AVYPHHGELV ALSPTGPNKK IKVELSAQGL SVQSYTMRGE
     FTESIDEKAS RAQSWKPDST TPGSPGLMEF VRAV