ID   MED17_BOVIN             Reviewed;         651 AA.
AC   Q5BIR6; Q3SYX5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 6;
DE            Short=CRSP complex subunit 6;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=MED17; Synonyms=CRSP6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with GATA1, PPARG
CC       and STAT2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; BT021158; AAX31340.1; -; mRNA.
DR   RefSeq; NP_001029902.2; NM_001034730.2.
DR   AlphaFoldDB; Q5BIR6; -.
DR   SMR; Q5BIR6; -.
DR   STRING; 9913.ENSBTAP00000004623; -.
DR   PaxDb; Q5BIR6; -.
DR   PRIDE; Q5BIR6; -.
DR   Ensembl; ENSBTAT00000004623; ENSBTAP00000004623; ENSBTAG00000003552.
DR   GeneID; 541303; -.
DR   KEGG; bta:541303; -.
DR   CTD; 9440; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003552; -.
DR   VGNC; VGNC:56273; MED17.
DR   eggNOG; KOG4512; Eukaryota.
DR   GeneTree; ENSGT00390000011810; -.
DR   HOGENOM; CLU_028003_1_0_1; -.
DR   InParanoid; Q5BIR6; -.
DR   OMA; CQIYQHQ; -.
DR   OrthoDB; 976669at2759; -.
DR   TreeFam; TF323615; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000003552; Expressed in spiral colon and 109 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:Ensembl.
DR   GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:Ensembl.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..651
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304699"
FT   REGION          51..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  72737 MW;  C2649A7F5B377E91 CRC64;
     MSGVRAVRIS IESACEKQVQ EVGLDGTETY LQPLSMSQNL ARLAQRIDFS QGSGSEEEEA
     AGAEGDAQDW AGAGSSADQD DEEGLVKFQP SLWPWDSVRN NLRSALTEMC VLYDVLSIVR
     DKKFMTLDPV SQDALPPKQN PQTLQLISKK KSLAGAAQIL LKGAERLTKS VTENQENKLQ
     RDFNSELLRL RQHWKLRKVG DKILGDLSYR SAGSLFPHHG TFEVIKNTDI DLDKKIPEDY
     CPLDVQIPSD LEGSAYIRVS IQKQAPDIGD LGTVNLFKRP LPKSKPGSPH WQTKLEAAQN
     VLLCKEIFAQ LSREAVQIKS QIPHIVVKNQ IISQPFPSLQ LSISLCHSSN DKKSPKSATE
     KQSPEDHLYV LEHNLHLLIR EFHKQTLSSI MMPHPASAPF GHKRMRLSGP QAFDKNEINS
     IQSSEGLLEK IIKQAKHIFL RSRTAATIDS LASRIEDPQI QAHWSNINDV YESSVKVLIT
     SQGYEQICKS IQLQLNIGVE QIRVVHRDGR VITLSHEGQE LQDFLLSQMS QHQVHAVQQL
     AKVMGWQVLS FSNHVGLGPV ESIGNASAIT VASPNGDYAI SVRNGPESGS KIMVQFPRNQ
     CKDLPKSDVL QDSKWNHLRG PFKEVQWNKM EGRNFVYKME LLMSALSPCL L