ID   MED17_CAEEL             Reviewed;         667 AA.
AC   Q9NAL4; G2HJZ8; G2HJZ9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 4.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=mdt-17; ORFNames=Y113G7B.18;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b;
CC         IsoId=Q9NAL4-1; Sequence=Displayed;
CC       Name=a;
CC         IsoId=Q9NAL4-2; Sequence=VSP_044225;
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AL110477; CCD31130.1; -; Genomic_DNA.
DR   EMBL; AL110477; CCD31131.1; -; Genomic_DNA.
DR   RefSeq; NP_001256909.1; NM_001269980.1. [Q9NAL4-2]
DR   RefSeq; NP_001256910.1; NM_001269981.1. [Q9NAL4-1]
DR   AlphaFoldDB; Q9NAL4; -.
DR   SMR; Q9NAL4; -.
DR   BioGRID; 45285; 4.
DR   IntAct; Q9NAL4; 2.
DR   STRING; 6239.Y113G7B.18b.2; -.
DR   EPD; Q9NAL4; -.
DR   PaxDb; Q9NAL4; -.
DR   PeptideAtlas; Q9NAL4; -.
DR   PRIDE; Q9NAL4; -.
DR   EnsemblMetazoa; Y113G7B.18a.1; Y113G7B.18a.1; WBGene00007017. [Q9NAL4-2]
DR   EnsemblMetazoa; Y113G7B.18a.2; Y113G7B.18a.2; WBGene00007017. [Q9NAL4-2]
DR   EnsemblMetazoa; Y113G7B.18b.1; Y113G7B.18b.1; WBGene00007017. [Q9NAL4-1]
DR   EnsemblMetazoa; Y113G7B.18b.2; Y113G7B.18b.2; WBGene00007017. [Q9NAL4-1]
DR   GeneID; 180325; -.
DR   KEGG; cel:CELE_Y113G7B.18; -.
DR   UCSC; Y113G7B.18.2; c. elegans. [Q9NAL4-1]
DR   CTD; 180325; -.
DR   WormBase; Y113G7B.18a; CE46431; WBGene00007017; mdt-17. [Q9NAL4-2]
DR   WormBase; Y113G7B.18b; CE46521; WBGene00007017; mdt-17. [Q9NAL4-1]
DR   eggNOG; KOG4512; Eukaryota.
DR   GeneTree; ENSGT00390000011810; -.
DR   InParanoid; Q9NAL4; -.
DR   OMA; CQIYQHQ; -.
DR   OrthoDB; 976669at2759; -.
DR   PhylomeDB; Q9NAL4; -.
DR   PRO; PR:Q9NAL4; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00007017; Expressed in embryo and 4 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; Coiled coil; Developmental protein;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..667
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304707"
FT   COILED          172..197
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         514..516
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_044225"
SQ   SEQUENCE   667 AA;  77018 MW;  378B784AC062BC06 CRC64;
     MEDGDEVVEP IEPESEDIVN LTKRLGVDLV LESNDDWKIQ EIGFDGVERY LQPETFTDHV
     GKLARKVEWT KLVGTKSPYE NSKVDPEDEL DDENVAKGGL NEELVTPEAG PWSSVAKYLH
     ESLNQLNSLL DVISVTKSTD YMKALTVLDP ITVQEPTPET ISTNRGTQWI WKRRALQEAV
     QVLDMAQKQR QRASSNLGLS ADYMAHLQRT KFFEELREMR EIWRVRKVGD YICGDLSYHI
     FGWKYDTPAI FDISRRSLSN NMENLSIIEV SVPKDLARRS MLAVSIVQDD IQSGNGLFRD
     PKDKKYTYSY RESDSEKVKL LHWKDSLKWA QNTLLLRDVF KTICTDAIKL RNRLSIIRDN
     VLLIHLFDDY LLRFELQWFP FQTGEIKEEG DIYLNRVLRE MIIGFECTKF IRPQFFCSMP
     VTHLPEALDL RGCGGFNTAQ IEERAVRSRS ILQRMLDVAS HRALVTMVSD VAERVSRISL
     DPTVQYRWLN CGRTTSRMMF NMTSKDFEMY IGTISSVRSV FFANISSDGV EVETKDGIKM
     KCQRDPARVM YACQYAMCCY SVTMVSTMSR NNNWVTPFQT MCANVFALDE RGNPAPNIVL
     CNQAATRSIL FVFHVGMEPE VFVRRFIVNE ETMKPEEHEW KKLCYSRLHG ATLCRKIDAL
     LVFLRDH