ID   MED17_CANAL             Reviewed;         565 AA.
AC   Q5AHZ7; A0A1D8PD37;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 3.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; OrderedLocusNames=CAALFM_C103530WA;
GN   ORFNames=CaO19.10573, CaO19.3055;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; CP017623; AOW26033.1; -; Genomic_DNA.
DR   RefSeq; XP_019330629.1; XM_019475084.1.
DR   AlphaFoldDB; Q5AHZ7; -.
DR   SMR; Q5AHZ7; -.
DR   BioGRID; 1220012; 2.
DR   STRING; 237561.Q5AHZ7; -.
DR   PRIDE; Q5AHZ7; -.
DR   GeneID; 3636918; -.
DR   KEGG; cal:CAALFM_C103530WA; -.
DR   CGD; CAL0000197516; MED17.
DR   VEuPathDB; FungiDB:C1_03530W_A; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_750039_0_0_1; -.
DR   InParanoid; Q5AHZ7; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   PRO; PR:Q5AHZ7; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..565
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304713"
FT   REGION          138..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  65595 MW;  211E72852FBE29A5 CRC64;
     MVEKQFNIDL ELNDTGHIDP FLQDEDKLKL EELIPRILFE RKSFLNVTED SLRKEIDNSL
     KISEEDALDT EESREDTVEA DQQEVFNKHK FELSKNINNA LNETQLSLDF VSLLISSVKP
     SLAKSTISPH LSKFVKPTSL NSDRLGQDSN DNQESKATDS FGQGWKLESL GKITDLFREA
     STNLNDQVIK ERRYWNMINL VLANDEVLFR MRDPQNNARA IGVKYGYGDS GSNFHDQGLA
     LLRKDNQTGE ISFHPISSIN NAKIVEKVSR FIRVKILSQI DGDYMLTGQS IFNFDFEKSK
     QSIINDIEKA RFFLFEEDLF HQLIREAKLL VNYNVSIISN KIIIEINNII IEIESIVYDE
     LNEEELENYY QNVNEYSTLH NKKCQLILNY LKLMLCCYYK YNLKLKQKVP TALTKWKQSN
     SHPLILRPLV GNMRHELNLL NMKSVLDRLM HAHESELSYS KLDVEKFINL ATRSKKQNPF
     QKSIEKPISK FHLVLCNKTS NMLDVNIQLT TNESFVNLII NMTIIRFETE DDFKNNVNGI
     NVLQLGFSDF NEIEECLDWS IQNFV