ID   MED17_CANGA             Reviewed;         676 AA.
AC   Q6FQ87;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; OrderedLocusNames=CAGL0I08261g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR380955; CAG60544.1; -; Genomic_DNA.
DR   RefSeq; XP_447607.1; XM_447607.1.
DR   AlphaFoldDB; Q6FQ87; -.
DR   SMR; Q6FQ87; -.
DR   STRING; 5478.XP_447607.1; -.
DR   PRIDE; Q6FQ87; -.
DR   EnsemblFungi; CAG60544; CAG60544; CAGL0I08261g.
DR   GeneID; 2889298; -.
DR   KEGG; cgr:CAGL0I08261g; -.
DR   CGD; CAL0132518; CAGL0I08261g.
DR   VEuPathDB; FungiDB:CAGL0I08261g; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_023188_0_0_1; -.
DR   InParanoid; Q6FQ87; -.
DR   OMA; PKINDKR; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0001139; F:RNA polymerase II complex recruiting activity; IEA:EnsemblFungi.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..676
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304714"
FT   REGION          27..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  76905 MW;  5F16D688EF1CFF55 CRC64;
     MTQLTENTDE LHSIRLAIDP NLITLPIGSK STSPHSNSTS DGNPESHNTE NEEVDNKAGS
     LPPEQFSNNS AKLIVNPYEK YGRMSLGQLI PLISQQRGPN FKFADINEDI LKQELAIEND
     NGKQESKDDT KAEDGIDTMD IDQNDNSEAN TNDIGYNEWS NEPKEDTGIL DNTQDTNING
     EMESQLTQEE FNKIRKVMLE HINMAMNESS LAMEFVSLLL SPVRESTAVS SMSPFLKKTV
     NPGSLNSEKV KMPAVSRRDK LSLSILSRGW KLRALNEARA ILKKNFTEIS SSLKQEHHYW
     SSIAYNISNK DVLFKIRDKQ TTKRSLGLKY GYEDSGSTFR NDRGTAILRG TDEANGLELI
     PLTLGRTSTV GSVYKGGKFL RVRIFTKIES EGDYILSGES SLDKLFKNHS ENSDSKNDDV
     RLQISKLKFF IFEQELMHQL KKECAYLISY GVTVENEHKI VIELPNEKFE IEYLSLDDDS
     VVNHEQDAPK ANDRRANLML VTLRMLLIVI YKKNLRQKMV SNTRKHIAST EKDILLIRPL
     LGKMRHSNHK KLIRKILKEC VLEVVPDTEL QERSIQSLDK EDFETFDLQD AHIVKLTKDI
     NAFRNVLDVG KTEFTIDMKQ SGKLSLILES PNYCNAQVSI KYDNQTSNTH FNTVSTEFKE
     VEEFLHFLIS TYVNPE