ID   MED17_CHICK             Reviewed;         643 AA.
AC   Q5ZID1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 6;
DE            Short=CRSP complex subunit 6;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=MED17; Synonyms=CRSP6; ORFNames=RCJMB04_27o3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ720853; CAG32512.1; -; mRNA.
DR   RefSeq; NP_001006280.1; NM_001006280.1.
DR   AlphaFoldDB; Q5ZID1; -.
DR   SMR; Q5ZID1; -.
DR   STRING; 9031.ENSGALP00000027778; -.
DR   PaxDb; Q5ZID1; -.
DR   GeneID; 419000; -.
DR   KEGG; gga:419000; -.
DR   CTD; 9440; -.
DR   VEuPathDB; HostDB:geneid_419000; -.
DR   eggNOG; KOG4512; Eukaryota.
DR   InParanoid; Q5ZID1; -.
DR   OrthoDB; 976669at2759; -.
DR   PhylomeDB; Q5ZID1; -.
DR   PRO; PR:Q5ZID1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; ISS:AgBase.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:AgBase.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:AgBase.
DR   GO; GO:0046966; F:nuclear thyroid hormone receptor binding; ISS:AgBase.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:AgBase.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:AgBase.
DR   GO; GO:0006351; P:transcription, DNA-templated; ISS:AgBase.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..643
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304701"
FT   REGION          50..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  72129 MW;  BD6019C076E0BFF1 CRC64;
     MAGVPAVRIS IESACEKQVQ EVGLDGSETY LQPLSMSQNL ARLAQRIDFS QGSGSEEDEP
     GSAGRAWAEP SEAEDEEGLV KFQPSLWPWD SVRNNLRSAL TEMCVLYDVL SIVKDKKFMT
     LDPVVQDPPP PKQDPQFLQL ISKKKSLAGA AQILLKGAER LSKSVAENQE NKRQRDFNSE
     LLRLRQHWKL RKVGDKILGD LSYRSAGSLF LHHGTFEVIK NTDIDLDKKI PEDYCPLDVQ
     IPSDLEGSAY IKVSIQKQAP DIGDLGTVNL FKRPMPKSKP GTPHWQTKLE TAQNVLLCKE
     IFAQLSREAV QIKSQIPHIV VKNQIISQPF PGLQLSISLC HSSNDKKSQK SASEKQNPEG
     HLYVLEHNLH QLIRECHKQT LSSVVMPHPA SAPFGHKRMR LAGPQAFDKN EISSLQTNEG
     LLEKIIKQAK HIFLRRRTAR TIDSLASRIE DPQIQAHWSN INDVYESSVK VLITSQGYEQ
     ICKSIQLQLN IGVEQIRVVH RDGRVITLSH QEQELQDFLL SQMSQHQVHA VQQLAKVMGW
     HVLSFSNHVG LGPVESIGNA SAITVASPNG DYAISVRNGP ESGSKVMVQF PRSQCKDLPK
     GDVLQDNKWN HLRGPFKEVQ WNKMEGRNFV YKMELLMAAL TPC