ID   MED17_COCIM             Reviewed;         691 AA.
AC   Q1DLD2; J3K1S5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; ORFNames=CIMG_08881;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; GG704913; EAS30135.3; -; Genomic_DNA.
DR   RefSeq; XP_001241718.1; XM_001241717.2.
DR   AlphaFoldDB; Q1DLD2; -.
DR   STRING; 246410.Q1DLD2; -.
DR   EnsemblFungi; EAS30135; EAS30135; CIMG_08881.
DR   GeneID; 4560685; -.
DR   KEGG; cim:CIMG_08881; -.
DR   VEuPathDB; FungiDB:CIMG_08881; -.
DR   InParanoid; Q1DLD2; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..691
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304715"
FT   COILED          158..185
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   691 AA;  78120 MW;  144647B31F7EC588 CRC64;
     MSNSFTLPLR PARQKANRED DLAVKIAQIN AQKGSFRDVT EASLLAEIEA ARAVGDGEAE
     AVDVKTGEDE EENREEKLFK SRLEISQFAM NAHMEATYAL EFVSLLLSKH APRQAETSMS
     PLLKQKVPLG SLGADHIKPP EQSETQKRDV DAVSRGWKLE SFDAAANKLL QSAQRLEEDI
     AAETKYWSEV LKIKEKGWKV CRLPQERQTL GVHFGFLEST QNFRDRGLAA LRKGEAGRLI
     LDRGIQLKPP RFVRVRVQRG DQTLGLTIPA ISKQLDDQCL DGRIREARDS LYEEELFYEL
     NREARVLLQY GVEIRRDLLK FPADDNKHIF VDLVGLDEAL PDIGGLDPLD NLLAEGVAKS
     FRILLSYAHR KNHHRRTRVP PPVTPNKRPA PEYNIIRPLL CYFQHRSHYQ WFTSFFGTLS
     KTLRSAGLKC SYTLYPLMKR PQSRAGSSQQ TLTVSSVERL IDTLINPSES IISCNLISQG
     SVFRVRITTN VNPNGLGSEF ELVTNLAHFP AQQSPFRFGL REDVRDLIIH LFTLDLVYLV
     PSLVKGSASA GASQYLISRY TGSQAFVEEE STDENEFAPS PAAKQDDVYL LPWQPTFPQQ
     GELTAYSPAR CRTKKLQIQL QSDQLQLRCF WVRHRGPSTK ADEQPGERLF TWRAVDMLGG
     AEESSRPTLQ RVMELLGEKY DDQTVQNIGS K