ID   MED17_DANRE             Reviewed;         643 AA.
AC   Q08BY1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 6;
DE            Short=CRSP complex subunit 6;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=med17; Synonyms=crsp6;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; BC124507; AAI24508.1; -; mRNA.
DR   RefSeq; NP_001071042.1; NM_001077574.1.
DR   AlphaFoldDB; Q08BY1; -.
DR   SMR; Q08BY1; -.
DR   STRING; 7955.ENSDARP00000023604; -.
DR   GeneID; 567560; -.
DR   KEGG; dre:567560; -.
DR   CTD; 9440; -.
DR   ZFIN; ZDB-GENE-040302-1; med17.
DR   eggNOG; KOG4512; Eukaryota.
DR   InParanoid; Q08BY1; -.
DR   OrthoDB; 976669at2759; -.
DR   PhylomeDB; Q08BY1; -.
DR   Reactome; R-DRE-212436; Generic Transcription Pathway.
DR   PRO; PR:Q08BY1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..643
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304702"
FT   REGION          53..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..80
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  72324 MW;  1DF4A90E681FD14A CRC64;
     MSGGPAVRVS IESSCERQVQ EVSLDGMETY VPPLSMSQNL AKLVQRIDFC QSSDSEEDGA
     ERARAGREQW KQEPEEDEGQ LKFQPSLWPW DSVRNNLRSA LTEMCVLHDV LSVLKERKYM
     TLDPVSQDPA MAKTPQVFQL ISKKKSLGTA AQLLLKGAEK LSKSVSENQE QRRQRDFNSE
     LLRLRSQWKL RKVGDKILGD LSYRSAGSLF PHHGTFEVIK NTDIDLDKKI PDDYCPLNVQ
     IPSDLEGSAY IKVSIQKQSP DIGDLGTVNL FRRQAKAKPA SQMWHSRLEA AQNVLLCKEI
     FAQLSREAVQ IKSQIPHIVV KNQIISQPFP GLQLSISLCH STGEKKSQRS SPDKSKPDDH
     LYVLEHNLHQ LIREFHKQTL SSVVMPHPAS APFGHKRLRL AGPLAYDKAE ISSLQQTEGL
     LEKIIKQAKH IFLRSRTART IDSLASRIED PQIQAHWSNI NDVYESSVKV LITSQGYEQI
     CKSIQLQLNI CVEQIRVVHR DGRVITLSHQ EQELQDFLLS QMSQHQVHAV QQLAKVMGWH
     VLSFSNHVGL GSIESIGNAS SITVASPSGE YAISVRNGPE SGCKVLVQFP RSQAKDAGRS
     DAVQDGKWTQ LRGAHREVHW DRMEGKNFVY KMELLMAALT PCP