MED17_DICDI
ID MED17_DICDI Reviewed; 856 AA.
AC Q54WH4; C7G012;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Putative mediator of RNA polymerase II transcription subunit 17;
GN Name=med17; ORFNames=DDB_G0279723;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=18515835; DOI=10.1093/nar/gkn349;
RA Bourbon H.-M.;
RT "Comparative genomics supports a deep evolutionary origin for the large,
RT four-module transcriptional mediator complex.";
RL Nucleic Acids Res. 36:3993-4008(2008).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000032; EEU04107.1; -; Genomic_DNA.
DR RefSeq; XP_002649159.2; XM_002649113.1.
DR AlphaFoldDB; Q54WH4; -.
DR SMR; Q54WH4; -.
DR STRING; 44689.DDB0266832; -.
DR PaxDb; Q54WH4; -.
DR GeneID; 8622154; -.
DR KEGG; ddi:DDB_G0279723; -.
DR dictyBase; DDB_G0279723; med17.
DR eggNOG; ENOG502RA18; Eukaryota.
DR HOGENOM; CLU_333852_0_0_1; -.
DR InParanoid; Q54WH4; -.
DR OMA; EINIDFP; -.
DR PRO; PR:Q54WH4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016592; C:mediator complex; ISS:dictyBase.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR019313; Mediator_Med17.
DR PANTHER; PTHR13114; PTHR13114; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Membrane; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..856
FT /note="Putative mediator of RNA polymerase II transcription
FT subunit 17"
FT /id="PRO_0000354049"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 55..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 41..91
FT /evidence="ECO:0000255"
FT COMPBIAS 63..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 93887 MW; 7C6D2FE77BBE6F79 CRC64;
MDFKISISIP PDNPPVAQVD HAGVEYPSIQ ISKSDKFIQI LNQAKHQKEI EQIKLNDNKN
NENNNLQDKE KEKEKEKERQ LQIQQQQQQV NPMISFHEHK NMARIELEQL IYLIDMLRNS
DQIQLNGNTK TPQKPIEQIW EITHRISHKQ QSLNNVASKL KLGATKMKDT ISTMSGWWND
VSQLRTKWRL KGKEQTGLSS AIANSMSGGG GGGGGSGGVG GVGVGGVGVG GIGGVVGGGG
LGNVGGLGGG IVGGVGGVAV GGVAVGGMVG ANGGGMVGSG GIQPGLNKSN AKRLSIDYGY
YSSGSFIEQT DADLSRGPNG EINIDFPHLP YQGSINKRLY INVKSSDSKT FFNHSSNLKK
LPSIPYQQLL NSATNSNNNS NRVNTPKTPT SSFPSTSSSA FNKLRQQQLQ QLQQQQQLQL
ENSDDPEEIH RKFIINCTNQ LNKAQKYQFN YEIFEQLSKE VSTINTSNSQ NLIGGGIGGV
NIGGGNVGVG GNVGGNVGGG GGGNTNYQTS PNIPSNQQVG TFQVGGSGVG SNLITMNPSL
NANTSSENIM LTEKEIRIEC GNFNLFIGMD TKVKEDNNNN NNNTNSNTNT NCKIKNNTSK
NIIYSDEEKN RLLFVLKTIL KKISVMQLKR SQKQLTFNLS RRTPKIIFGK KSIIGYNDDI
IFKITSIVKH MDTYLRVYKV LEIFERNLPI RLKSTPAAES ASSLFILTLI DSSQNLKNPM
VPIEISINQN KIEVIQGQNR SFSNKDEIIL GSFIINLLKS YFLNNNIHPS HLDIVGFDEN
DEQDQNNINN NINNQPKRYK FSNDQSSIIL ANNNNININN NNINNNSNFD DNFIKSNRNY
QIEKFFKGLV DEISNK
