ID   MED17_EMENI             Reviewed;         632 AA.
AC   Q5B8A6; C8VI82;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=srb4; Synonyms=med17; ORFNames=AN3224;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; AACD01000054; EAA63125.1; -; Genomic_DNA.
DR   EMBL; BN001306; CBF83151.1; -; Genomic_DNA.
DR   RefSeq; XP_660828.1; XM_655736.1.
DR   AlphaFoldDB; Q5B8A6; -.
DR   STRING; 162425.CADANIAP00009838; -.
DR   EnsemblFungi; CBF83151; CBF83151; ANIA_03224.
DR   EnsemblFungi; EAA63125; EAA63125; AN3224.2.
DR   GeneID; 2874164; -.
DR   KEGG; ani:AN3224.2; -.
DR   VEuPathDB; FungiDB:AN3224; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   InParanoid; Q5B8A6; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000000560; Chromosome VI.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..632
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304716"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   632 AA;  71644 MW;  B41C225C8FCE02CC CRC64;
     MSDSFTVSLR PIREKRDRPD SLPREIAQIN AQWGSFRELS EAKLREMIEE DKHKDHWEED
     DEGDKESTDL ETSEQLDQLY KRRAEIIQYA LQAHMEASFA LDFVSLLLSK HQPRQAETSM
     SPFLKSAAPL GSLNSEVVNP PPRPDSTLKD IKSVARGWRL QNFNSAADKL LNAGSRLETE
     VNSETKYWNE VLAVKEKGWK ICRLPRESQA LGVQYGFLEA TPIFRDRGLA ALRRTDDGSL
     FLDKGLIPLK SQGVRVRVRR GDRIVGCSKV CRPPQDAESI ESRILQARDT VFEEELFYEV
     MREARILGTQ GVKTRQNLVQ VPVSDEQEIL LDLVDWDQDR DPDAADSTEQ DVFADAVAHS
     IRILLTYAHR QNLRRRTQPP PPLAPKRRPV PEYHILRPIM AYLQHKSHIQ WLESLINDLR
     GVLQSAGIPC DFKATQFSSI GTLQPSNQVP KVEAVAGVFL APFLSTFSGN LVTPQSSFRI
     QIRTNLAVPP FGTFYELSVN LPQYPDVQPP NHVGLQDEVS AILTHVIMLD IAAAIPLQCR
     DTADKEAKER VSWDVDYPHH GELHFLSRNG QSRKMKISLS RQELTIETYQ LNRMRGVTPG
     AATSPTLWQT WRADSPETRP TLSEFVAQAS QP