ID   MED17_KLULA             Reviewed;         671 AA.
AC   Q6CR96;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; OrderedLocusNames=KLLA0D10802g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382124; CAH00639.1; -; Genomic_DNA.
DR   RefSeq; XP_453543.1; XM_453543.1.
DR   AlphaFoldDB; Q6CR96; -.
DR   SMR; Q6CR96; -.
DR   STRING; 28985.XP_453543.1; -.
DR   EnsemblFungi; CAH00639; CAH00639; KLLA0_D10802g.
DR   GeneID; 2893583; -.
DR   KEGG; kla:KLLA0_D10802g; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_023188_0_0_1; -.
DR   InParanoid; Q6CR96; -.
DR   OMA; PKINDKR; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0001139; F:RNA polymerase II complex recruiting activity; IEA:EnsemblFungi.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..671
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304717"
FT   REGION          104..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  75889 MW;  B096048C75B6B631 CRC64;
     MDGFSEYDPE KGIPLAIDPN LISIPVSTSL TTNGNGDEGV NNEDATVFAA DDADNAKSQK
     SLIQNPYEYF GQMPLEQFIP LMLQQRGTGT KFADIHEETL LEEISRENSS KSNNAIQEED
     NDDSAIQNVD EKTTTVVNEG VSDSHEMKDE DGDVNMDVPS VESSPKLAEE REPTADANDA
     QRAISGNQEE SITLEEFKMI KKNVLEHVNM ALNESSLSLE FVSLLLSSTR TSAGISSMSP
     YLKKIAPPAS LNADKVPLDI LDEHEKLTYD IIHKGWNLRS LEDCKRLLKQ HYQILSKSVE
     SEYHYWKQIS DNITNKDVLF KMKDKNTGRR TLGIKYGFDD SGSCYSADKG IALLRATSEG
     SQLELVPIID SGINVGISRG SSEQFVRVRI FTKIEQEDDY LLSGQSSLNE LLLSSRSDIK
     SQIAKLRFFI FEKELMHQLK KEAGQLLPYG VSVENENKVL LELSNEKIEF ELINLDEEVT
     SNYQQEAAKV NDKRANLILV MLNMLLVVMY KKQLWKRLNP NPHSSKSSKG YGKDLVLLRA
     ILGKIRHKKY TQLIEKIVNN AILEKKEDSI MTTNTDITSN DNEPSKNKEL ATLQREIALF
     DKILSMPRTD FTINIPEKGK LELSLRSTNH CNAIIHMKYI DVGQVVKFDT RFSEFTEFEE
     FLNFVYNEFL I