ID   MED17_NEOFI             Reviewed;         639 AA.
AC   A1CV59;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=srb4; Synonyms=med17; ORFNames=NFIA_044550;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; DS027684; EAW25636.1; -; Genomic_DNA.
DR   RefSeq; XP_001267533.1; XM_001267532.1.
DR   AlphaFoldDB; A1CV59; -.
DR   STRING; 36630.CADNFIAP00003986; -.
DR   EnsemblFungi; EAW25636; EAW25636; NFIA_044550.
DR   GeneID; 4594333; -.
DR   KEGG; nfi:NFIA_044550; -.
DR   VEuPathDB; FungiDB:NFIA_044550; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   OMA; GVTTRQN; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..639
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304718"
FT   COILED          160..187
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   639 AA;  72201 MW;  A7487BC5842D9871 CRC64;
     MADDKFTLPL RPLIEKRDRP DPLPLEIAQI NAQWGSFRDV SEESLRAKIE EEKSKEYTIE
     EEEGEGAGAE LDTTERLDQL YKRRAEIIQF AMQAHMEAMF ALDFISLLLS KHTPRQAETS
     MSAYLKQVAP LGSLNSEIIS PPPKSEAVVR DTKTVSRGWR LQNFNAAADK LLKSASRLEN
     EVASETRYWH EVLAVKDKGW KLCRLPRQGQ TLGVQYGFLE ATPIFRDRGL AALRRSQDGA
     LILDKGLVPM KAKTVRVRVK DHGIITGCSK PYRSAAQDPD SIEGRILQAR DTLFEEELFH
     ELFREARIMG SQGVTTRQNM VQFPVSEEQD ILLDLVDPYQ EAYVDDEETK SEEHNVLADA
     LAHSIRILLC YAHRQNLRRR TQPPPALSPR RRHIPEYQLL RPIMAYLQHS FHVRWLETFM
     KDVYGVLQSA GLSCSFTATP YSSVNLSNSD RSVPKVEGLI RQFLLPLETT FSADLLTPQS
     SFKVKTRTNL SVPPFGTHFE ILLNLPHYPD VHSPHRIGLH DQAATIITHF IMLDIVAAIE
     SQTSPASSIS KTEAKSVSWE ATYPHHGELL SVSIDGKQKK MKVILSRDEL TVQTYDVQGV
     ERYSRATPET TPGLQTHTWK AGPTTAPGLM EYVAAVSQR