ID   MED17_PICST             Reviewed;         587 AA.
AC   A3LRF0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 3.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; ORFNames=PICST_30665;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABN65725.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CP000497; ABN65725.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001383754.2; XM_001383717.1.
DR   AlphaFoldDB; A3LRF0; -.
DR   STRING; 4924.XP_001383754.2; -.
DR   EnsemblFungi; ABN65725; ABN65725; PICST_30665.
DR   GeneID; 4838142; -.
DR   KEGG; pic:PICST_30665; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_750039_0_0_1; -.
DR   InParanoid; A3LRF0; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000002258; Chromosome 3.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..587
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304719"
FT   REGION          156..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  67458 MW;  3FFF2B76ED7AAF88 CRC64;
     MFSNGHFHID LDPDAYGDAN KDPFIQDEDK LTIAELIPRI LIERNSFLNV TEESLQEEID
     NPRAEDEANN EVDVASELDI GDESVENGSI LMATLAETSL DPVELFQKQK LDLSKSINSA
     LNETSLSLDF VSLLISSVKP NLAKSTISPH LNKSVPLGSL NSDRLSNEND DDDRNKSVAP
     KETPKVGHGW KLESLHKVTS LFREASENLN EQVLKERRYW NMINSVLTND EVLFKTRDPL
     NNARAIGVKY GYGDSGSNFH DKGLAILRKD TVTGEISFNP INYAHKLTSK VFRYIRIKIL
     SEIDGDFMLT GQSLFENDFS SSKDQIINDI EKARFFLFEE DLFYQLTREA KTLINYNVSI
     ISNKIIIEIN NEIIEIESVV YDENNDDELN NYYQNINAYS SINNGKCQLI LKFFKIMLCC
     YYKYNLKLKQ KIPTSLTKWK QSNSHPLVLR PLLGNIRHEL NLKNMQSIID RLIAKFKESL
     ECKLQVDKFA NLEHRSENPF QKSIERPVSK FNIVLKSKRS AYLKIDLELT TNEIFVNLII
     NMNVIKFKCE DDFKNNFNGV NVLQINFNDF HEIEECLDWT LLNFVNG