ID   MED17_XENTR             Reviewed;         639 AA.
AC   Q0VFR9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 6;
DE            Short=CRSP complex subunit 6;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=med17; Synonyms=crsp6;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; BC118725; AAI18726.1; -; mRNA.
DR   RefSeq; NP_001016974.1; NM_001016974.3.
DR   AlphaFoldDB; Q0VFR9; -.
DR   SMR; Q0VFR9; -.
DR   STRING; 8364.ENSXETP00000037314; -.
DR   PaxDb; Q0VFR9; -.
DR   DNASU; 549728; -.
DR   Ensembl; ENSXETT00000037314; ENSXETP00000037314; ENSXETG00000017118.
DR   GeneID; 549728; -.
DR   KEGG; xtr:549728; -.
DR   CTD; 9440; -.
DR   Xenbase; XB-GENE-1008314; med17.
DR   eggNOG; KOG4512; Eukaryota.
DR   HOGENOM; CLU_028003_1_0_1; -.
DR   InParanoid; Q0VFR9; -.
DR   OMA; NENERQY; -.
DR   OrthoDB; 976669at2759; -.
DR   PhylomeDB; Q0VFR9; -.
DR   TreeFam; TF323615; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017118; Expressed in neurula embryo and 12 other tissues.
DR   ExpressionAtlas; Q0VFR9; differential.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..639
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304703"
SQ   SEQUENCE   639 AA;  72290 MW;  410D7A5BA38B5A49 CRC64;
     MSGVPAVNIS IESSAEKQVQ EVGLDGSETY VLPLSMSQNL ARLAQRIDFS QESGEEEAEA
     ARELEWAEQE EEEGLVKFQP SLWPWDSVRN NLRSTLTEMC VLYDVLNIVK EKRYMHLDPV
     SQEALPPKPN QHGLLLVSKK KSLAAAAQIL LKGAERLSKS VAENQENKRQ RDFNSELLRL
     RQHWKLRKLG DKILGDLSYR SAGSLFPHHG TFEVIKNTDI DLDKKMPEDY CPLDVHIPSD
     LEGSAYLKVS IQKQAPDIGD LGTVNLFRRP LPKAKPGTPH WQTRLEAAQN VLLCKEVFAQ
     LSREAVQIKS QIPHIVVKNQ IISQPFPGLQ LSISLCHSSN DKKSQKSNSD KMGAEDHLYV
     LEHNLHQLIR EFHKQTLSNI VMPHPASAPF GHKRMRLAGP QAFDKNEMGF MQQNEGLLEK
     IIKQAKHIFL RRRTARTIDS LASRIEDPQI QAHWSSINDV YESSVKVLIT SQGYEQICKS
     IQLQLNIGVD QIRVVHRDGR VITLSHQEQE LQDFLLSQMS QHQVLAVQQL AKVMGWHVLS
     FTNHVGLGQV ESVGNASSIT VTSPNGDYAI SVRNGPESGT KVMVQFPRSQ CKDLPKGDVL
     QENKWQYLRG PYKEVQWNKM EGRNFVYKME LLMAALTPC