ID   MED17_YARLI             Reviewed;         511 AA.
AC   Q6C022;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17;
DE   AltName: Full=Mediator complex subunit 17;
GN   Name=SRB4; Synonyms=MED17; OrderedLocusNames=YALI0F28435g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382132; CAG78802.1; -; Genomic_DNA.
DR   RefSeq; XP_505990.1; XM_505990.1.
DR   AlphaFoldDB; Q6C022; -.
DR   SMR; Q6C022; -.
DR   STRING; 4952.CAG78802; -.
DR   EnsemblFungi; CAG78802; CAG78802; YALI0_F28435g.
DR   GeneID; 2908851; -.
DR   KEGG; yli:YALI0F28435g; -.
DR   VEuPathDB; FungiDB:YALI0_F28435g; -.
DR   HOGENOM; CLU_015164_1_0_1; -.
DR   InParanoid; Q6C022; -.
DR   OMA; PKINDKR; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..511
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   17"
FT                   /id="PRO_0000304720"
SQ   SEQUENCE   511 AA;  56150 MW;  E1239933DF4508C7 CRC64;
     MSDIKVTLAV EDRAENQDTL SISEIVPRIV AERKSFVDVT EESLLEEIAN CVADSADDNV
     KDEVDEKPDE SPFDQHRLKL LENVKAAYNE SALALDFVSL LISSVRPTSA STSMSPHLKT
     HIPVGSLGAD RVPAPQVANE PGVGIGWKIE SLTNARDRLK TCASRLRTEA AKEKTYWAGV
     ASIAATGEVL FKVRNSDTRG LGIKYGFGDA GSKYRDPGIG VLKRSATGTV DFEPKEEVQK
     KFVRVTIKSE EGEVTKSVSN VYTRDSKPPT DPTLAAIHET RHALFEEELF FEIAREARLL
     TSRKVTVADG AVTVDLGEGD MVVIEWVEVP EEPTTTFAPS LANLFVLALR LLLANAHRQQ
     LEKMRTPPAP LQSKGGPNPN PPLPILRPLL AHILHKRLVS RARRSLYLLS TTHSGLSFEI
     TTNNSTDKES SSLGRLMAAP VSNLKIKFSD KGNAKVVIPS PLQSHQSMFD VTMFKGTSQE
     TVTSHTGFHE LVELEEWVRW AADRSEPKKS N