ID   MED18_ANOGA             Reviewed;         211 AA.
AC   Q7QGX9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=MED18; ORFNames=AGAP010936;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA05528.4; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AAAB01008823; EAA05528.4; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_309758.4; XM_309758.5.
DR   AlphaFoldDB; Q7QGX9; -.
DR   SMR; Q7QGX9; -.
DR   STRING; 7165.AGAP010936-PA; -.
DR   PaxDb; Q7QGX9; -.
DR   GeneID; 1271016; -.
DR   KEGG; aga:AgaP_AGAP010936; -.
DR   CTD; 1271016; -.
DR   VEuPathDB; VectorBase:AGAP010936; -.
DR   eggNOG; KOG3264; Eukaryota.
DR   HOGENOM; CLU_084570_0_0_1; -.
DR   InParanoid; Q7QGX9; -.
DR   OrthoDB; 1140930at2759; -.
DR   Proteomes; UP000007062; Chromosome 3L.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 2.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..211
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304748"
SQ   SEQUENCE   211 AA;  23867 MW;  E14A516B1B5AD800 CRC64;
     MGAQVNAAEL LQQALSSNII PNQEFLLQGS ILDSAAENLL HRLRGLCDNV DASPETFSDI
     EMCFSLKLPT EKTPVMTVRV RRAQDVEAPL QLRYIGQPEL GDRTRPTLVR SSLDIACTPH
     VIDFLTEMGF RLDFEYSTKG YMFRKGRMKI TVSKILKNMT EPISQSYLVE LSVLAPKGQD
     AIAEDMRIFA EQLKPLVQLE KIDYKRFAQM P