ID   MED18_ASPCL             Reviewed;         278 AA.
AC   A1CE73;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=srb5; Synonyms=med18; ORFNames=ACLA_088610;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; DS027052; EAW11172.1; -; Genomic_DNA.
DR   RefSeq; XP_001272598.1; XM_001272597.1.
DR   AlphaFoldDB; A1CE73; -.
DR   SMR; A1CE73; -.
DR   STRING; 5057.CADACLAP00008373; -.
DR   EnsemblFungi; EAW11172; EAW11172; ACLA_088610.
DR   GeneID; 4704935; -.
DR   KEGG; act:ACLA_088610; -.
DR   VEuPathDB; FungiDB:ACLA_088610; -.
DR   eggNOG; ENOG502S7EN; Eukaryota.
DR   HOGENOM; CLU_084516_0_0_1; -.
DR   OMA; PVHQHHE; -.
DR   OrthoDB; 1167687at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..278
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304753"
SQ   SEQUENCE   278 AA;  30905 MW;  D60A731597954790 CRC64;
     MHELLLFASV PAHQHHELLQ QLAGLTAMQP QHRFERRLIF KAYRKPGLVN VRVGASQDVQ
     GAEMQRLNKM LNGGMFYTQV VGPVAAADFG APAPTVSVGD QDAQMSGMGV GVSAGVDEKP
     STRPHRYDYD DQPWKLEFRD IPEAGTRSAV TARLMASASL PRGDIMVPMN AWGYNFVTEY
     AVEGDIFILH DIVIFLHRVL HYPTESQEPR RQLPALPEMT PLERSGSYVL QAAITVQDGA
     SQETMKIASQ HLFGLREQLK SAVRLEMADR LSLDTRAK