ID   MED18_ASPNC             Reviewed;         271 AA.
AC   A2RBB7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=srb5; Synonyms=med18; ORFNames=An18g06160;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; AM270411; CAK43341.1; -; Genomic_DNA.
DR   RefSeq; XP_001399069.1; XM_001399032.2.
DR   AlphaFoldDB; A2RBB7; -.
DR   PaxDb; A2RBB7; -.
DR   EnsemblFungi; CAK43341; CAK43341; An18g06160.
DR   GeneID; 4990184; -.
DR   KEGG; ang:ANI_1_816164; -.
DR   VEuPathDB; FungiDB:An18g06160; -.
DR   HOGENOM; CLU_084516_0_0_1; -.
DR   Proteomes; UP000006706; Chromosome 8L.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..271
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304755"
FT   REGION          89..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  30045 MW;  D707B3DE3828C8F6 CRC64;
     MHELLLFASV PAHQHHELLQ QLAGLTAMQP RHRLERRLVF KAYRKPGLTN TRVGASQDLQ
     GVELQRLNKM LNGGMFYTQV VGPVAKADFG GNPSSSGDPD VSMSGLEEKP SSSSSSYSYE
     DQPWKLEFRD IPEAGTRSAV TARLMASATL PKGDITAPMN AWGYSFVTEY VVEGDVFVLN
     DIVIFLHRVL LYPTGAQESH GPRRQLPAYQ ELSPLERTGS YVLQAAITVQ DGGNQEMMRT
     ASQHLFGLRE QLKSAVRLEM ADRLSLDTRA K