ID   MED18_BOVIN             Reviewed;         208 AA.
AC   Q0VCD4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=MED18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; BC120223; AAI20224.1; -; mRNA.
DR   RefSeq; NP_001069703.1; NM_001076235.2.
DR   RefSeq; XP_005203285.1; XM_005203228.3.
DR   AlphaFoldDB; Q0VCD4; -.
DR   SMR; Q0VCD4; -.
DR   STRING; 9913.ENSBTAP00000003468; -.
DR   PaxDb; Q0VCD4; -.
DR   PRIDE; Q0VCD4; -.
DR   Ensembl; ENSBTAT00000003468; ENSBTAP00000003468; ENSBTAG00000002678.
DR   GeneID; 540695; -.
DR   KEGG; bta:540695; -.
DR   CTD; 54797; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002678; -.
DR   VGNC; VGNC:31355; MED18.
DR   eggNOG; KOG3264; Eukaryota.
DR   GeneTree; ENSGT00390000003312; -.
DR   HOGENOM; CLU_084570_0_0_1; -.
DR   InParanoid; Q0VCD4; -.
DR   OMA; PTSPWHL; -.
DR   OrthoDB; 1140930at2759; -.
DR   TreeFam; TF313246; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000002678; Expressed in oocyte and 107 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 2.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..208
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304741"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUE0"
SQ   SEQUENCE   208 AA;  23682 MW;  749FAB76F6084D2D CRC64;
     MEAPPVTMMP VTGGTINMME YLLQGSVLDH SLESLIHRLR GLCDNMEPET FVDHEMVFLL
     KGQQASPFVL RARRSLDRAG APWHLRYLGQ PEMGDKNRHA LVRNCVDIAT SENLTDFLME
     MGFRMDHEFV ARGHLFRKGI MKIVVYKIFR ILVPGNTDNT EALSLSYLVE LSVVAPAGQD
     MVSDDMRNFA EQLKPLVHLE KIDPKRLM