ID   MED18_CAEBR             Reviewed;         227 AA.
AC   Q61D43; A8XG84;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=mdt-18; ORFNames=CBG12642;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600940; CAP31590.1; -; Genomic_DNA.
DR   RefSeq; XP_002640143.1; XM_002640097.1.
DR   AlphaFoldDB; Q61D43; -.
DR   SMR; Q61D43; -.
DR   STRING; 6238.CBG12642; -.
DR   GeneID; 8582139; -.
DR   KEGG; cbr:CBG_12642; -.
DR   CTD; 8582139; -.
DR   WormBase; CBG12642; CBP42492; WBGene00033560; Cbr-mdt-18.
DR   eggNOG; KOG3264; Eukaryota.
DR   HOGENOM; CLU_084570_0_0_1; -.
DR   InParanoid; Q61D43; -.
DR   OMA; PTSPWHL; -.
DR   OrthoDB; 1140930at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..227
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304750"
SQ   SEQUENCE   227 AA;  26012 MW;  74F64EF2D7B652DB CRC64;
     MDNVVDVDEE GNQQKLSANS TPYQTQECVL YGSIFVKNVP DLERRLAGLW IRAAKNSMST
     KCRSALEPPV HQILRRRFRT EHQIQNYWQL KYIGVPEPDQ KCPTIVRKEI SSLVHSQDMM
     TYAKSLGLRM DYEYITQGKL WTKGNIKILH STLTRTLRAG TYDSSSLKSM SDSALVEISI
     SLPESAEYMP AAKSLRDFAD QLMPLVNMEK IDYWKKMFST PAAPARR